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Self-Rolling Refillable Tubular Enzyme Containers Made ofRecombinant Spider Silk and Chitosan

Title data

Aigner, Tamara ; Scheibel, Thomas:
Self-Rolling Refillable Tubular Enzyme Containers Made ofRecombinant Spider Silk and Chitosan.
In: ACS Applied Materials & Interfaces. Vol. 11 (29 March 2019) Issue 17 . - pp. 15290-15297.
ISSN 1944-8252
DOI: https://doi.org/10.1021/acsami.9b01654

Abstract in another language

Encapsulation of enzymes is often necessary to stabilize them against environmental conditions or to protect them from other harmful enzymes such as proteases. Here, a refillable spatial confinement system was produced using a fully degradable self-rolling biopolymer bilayer. The enzyme containers comprise spider silk and chitosan and enable one-pot reactions in the micro- to milliliter regime by trapping the enzyme inside the semipermeable tube and allow the substrate and/or product either to diffuse freely or to be entrapped. The tubes are stable toward several organic and aqueous solvents. A one-tube system with esterase-2 was used to establish the system. Further, a two-tube system was applied to mimic enzymatic cascades, where the enzymes have to be separated, because they, for example, inhibit each other. The entrapment mode was also tested in the two-tube system, which is beneficial for toxic products or for obtaining high concentrations of the desired product.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: recombinant spider silk; layer-by-layer assembly enzyme catalysis microstructures; stimuli-responsive materials
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 20 Jan 2020 11:51
Last Modified: 20 Jan 2020 11:51
URI: https://eref.uni-bayreuth.de/id/eprint/54144