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Ultrathin Spider Silk Films : Insights into Spider Silk Assembly on Surfaces

Title data

Borkner, Christian B. ; Lentz, Sarah ; Müller, Martin ; Fery, Andreas ; Scheibel, Thomas:
Ultrathin Spider Silk Films : Insights into Spider Silk Assembly on Surfaces.
In: ACS Applied Polymer Materials. Vol. 1 (30 October 2019) Issue 12 . - pp. 3366-3374.
ISSN 2637-6105
DOI: https://doi.org/10.1021/acsapm.9b00792

Abstract in another language

β-Sheets in natural spider dragline silk proteins are typically formed by polyalanine (An) as well as alanine-glycine (AG) and GGA sequences flanking these An regions. The hydrophobic β-sheet-rich regions are embedded in a hydrophilic amorphous matrix, and this phenomenon can be reflected as microphase separation, similar to that of block copolymers. Microphase separation occurs not only in fibers but also in cast spider silk films. Micellar-like structures form within the bulk of the film, while substrate surface as well as the film/air interface trigger explicit secondary structure formation in these layers. So far, only limited information is available concerning the mechanism of film assembly and microphase separation of spider silk proteins on surfaces. In this work, self-assembly and folding of eADF4(C16) was analyzed on steady silicon surfaces, dependent on the spider silk layer number and thickness. Based on the results, a model for structural features of spider silk films is proposed, combining block copolymer microphase separation theory with folding properties of recombinant eADF4(C16).

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: spider silk protein structure self-assembly; spin-coating microphase separation
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 20 Jan 2020 12:24
Last Modified: 16 Mar 2020 09:55
URI: https://eref.uni-bayreuth.de/id/eprint/54159