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Optimization of lead compounds into on-demand, nonhormonal contraceptives : leveraging a public-private drug discovery institute collaboration

Title data

Balbach, Melanie ; Fushimi, Makoto ; Huggins, David J. ; Steegborn, Clemens ; Meinke, Peter T. ; Levin, Lonny R. ; Buck, Jochen:
Optimization of lead compounds into on-demand, nonhormonal contraceptives : leveraging a public-private drug discovery institute collaboration.
In: Biology of Reproduction. Vol. 103 (August 2020) Issue 2 . - pp. 176-182.
ISSN 1529-7268
DOI: https://doi.org/10.1093/biolre/ioaa052

Abstract in another language

Efforts to develop new male or female nonhormonal, orally available contraceptives assume that to be effective and safe, targets must be (1) essential for fertility; (2) amenable to targeting by small-molecule inhibitors; and (3) restricted to the germline. In this perspective, we question the third assumption and propose that despite its wide expression, soluble adenylyl cyclase (sAC: ADCY10), which is essential for male fertility, is a valid target. We hypothesize that an acute-acting sAC inhibitor may provide orally available, on-demand, nonhormonal contraception for men without adverse, mechanism-based effects. To test this concept, we describe a collaboration between academia and the unique capabilities of a public-private drug discovery institute.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Apacitation; Male contraception; Soluble adenylyl cyclase
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Clemens Steegborn
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 07 Sep 2020 07:37
Last Modified: 07 Sep 2020 07:37
URI: https://eref.uni-bayreuth.de/id/eprint/56810