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Spider Silk Fusion Proteins for Controlled Collagen Binding and Biomineralization

Title data

Neubauer, Vanessa ; Scheibel, Thomas:
Spider Silk Fusion Proteins for Controlled Collagen Binding and Biomineralization.
In: ACS Biomaterials Science & Engineering. (18 August 2020) .
ISSN 2373-9878
DOI: https://doi.org/10.1021/acsbiomaterials.0c00818

Abstract in another language

The development of biomaterials for the interfacebetween tendon and bone is important for realizing functional tendonreplacements. Toward the development of new materials for suchapplications, engineered recombinant spider silk proteins were modifiedwith peptide tag sequences derived from noncollagenous proteins inbone, so-called SIBLING proteins, such as osteopontin and sialoprotein,which are known to interact with collagen and to initiate mineralization.Materials made of these spider silk−SIBLING hybrids were analyzedconcerning mineralization and interaction with cells. They showedenhanced calcium phosphate formation upon incubation in mineraliza-tion agents. In gradientfilms, MC3T3-E1 mouse preosteoblasts adheredpreferentially along the gradient toward the variant with a collagen binding motif.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: recombinant spider silk; calcium phosphate; biomineralization; osteopontin; sialoprotein; gradient materials
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 02 Oct 2020 05:27
Last Modified: 02 Oct 2020 05:27
URI: https://eref.uni-bayreuth.de/id/eprint/57774