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Interplay of Different Major Ampullate Spidroins during Assembly and Implications for Fiber Mechanics

Title data

Saric, Merisa ; Eisoldt, Lukas ; Döring, Volker ; Scheibel, Thomas:
Interplay of Different Major Ampullate Spidroins during Assembly and Implications for Fiber Mechanics.
In: Advanced Materials. (26 January 2021) .
ISSN 1521-4095
DOI: https://doi.org/10.1002/adma.202006499

Official URL: Volltext

Abstract in another language

Major ampullate (MA) spider silk has fascinating mechanical properties combining strength and elasticity. All known natural MA silks contain at least two or more different spidroins; however, it is unknown why and if there is any interplay in the spinning dope. Here, two different spidroins from Araneus diadematus are co‐produced in Escherichia coli to study the possible dimerization and effects thereof on the mechanical properties of fibers. During the production of the two spidroins, a mixture of homo‐ and heterodimers is formed triggered by the carboxyl‐terminal domains. Interestingly, homodimeric species of the individual spidroins self‐assemble differently in comparison to heterodimers, and stoichiometric mixtures of homo‐ and heterodimers yield spidroin networks upon assembly with huge impact on fiber mechanics upon spinning. The obtained results provide the basis for man‐made tuning of spinning dopes to yield high‐performance fibers.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: Bioinspired fibers; Heterodimers; Protein interplay; Self‐assembly; Spider silk
Institutions of the University: Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Emerging Fields
Profile Fields > Emerging Fields > Food and Health Sciences
Research Institutions
Research Institutions > Research Centres
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences
600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 02 Feb 2021 08:58
Last Modified: 15 Feb 2021 06:12
URI: https://eref.uni-bayreuth.de/id/eprint/62681