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Lipid-Specific β‑Sheet Formation in a Mussel Byssus Protein Domain

Title data

Heim, Markus ; Elsner, Martina B. ; Scheibel, Thomas:
Lipid-Specific β‑Sheet Formation in a Mussel Byssus Protein Domain.
In: Biomacromolecules. Vol. 14 (2013) Issue 9 . - pp. 3238-3245.
ISSN 1526-4602
DOI: https://doi.org/10.1021/bm400860y

Abstract in another language

Intrinsically disordered proteins (IDP) or regions (IDR)
can adopt multiple conformational states, depending on the interaction
partners they encounter. This enables proteins or individual domains to
fulfill multiple functions. Here, we analyzed the flank sequences of
preCol-NG, one of three collagenous proteins of a mussel byssus thread
governing its mechanical performance. preCol-NG comprises a collagen
domain and nonrepetitive termini enclosing specific flank regions
characterized by tandem repeats known from silk proteins, protein
elastomers, and plant cell wall-associated proteins. We recombinantly
produced a protein mimicking the M. galloprovincialis preCol-NG Cterminal
flank region. The protein was intrinsically unfolded in solution, even at elevated temperatures. However, upon contact
with small unilamellar vesicles (SUVs) reversible β-structure formation occurred, reminiscent of partitioning-folding coupling.
This behavior of preCol-NG flank domains likely impacts byssogenesis and sheds new light on a distinct mechanism of how
fibrous protein materials might be achieved by lipid-induced self-assembly in nature.

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties
Faculties > Faculty of Engineering Science
Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel
Research Institutions > Research Centres > Bayreuth Center for Colloids and Interfaces - BZKG
Research Institutions > Research Centres > Bayreuth Center for Molecular Biosciences - BZMB
Research Institutions > Research Centres > Research Center for Bio-Macromolecules - BIOmac
Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT
Faculties > Faculty of Engineering Science > Chair Biomaterials
Research Institutions
Research Institutions > Research Centres
Profile Fields > Advanced Fields > Advanced Materials
Profile Fields > Advanced Fields > Molecular Biosciences
Profile Fields > Advanced Fields > Polymer and Colloid Science
Profile Fields > Emerging Fields > Food and Health Sciences
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Emerging Fields
Result of work at the UBT: Yes
DDC Subjects: 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited: 25 Feb 2015 06:05
Last Modified: 26 Nov 2015 10:51
URI: https://eref.uni-bayreuth.de/id/eprint/6672