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Solution structure, dynamics, and hydrodynamics of the calcium-bound cross-reactive birch pollen allergen Bet v 4 reveal a canonical monomeric two EF-hand assembly with a regulatory function

Title data

Neudecker, Philipp ; Nerkamp, Jörg ; Eisenmann, Anke ; Nourse, Amanda ; Lauber, Thomas ; Schweimer, Kristian ; Lehmann, Katrin ; Schwarzinger, Stephan ; Ferreira, Fátima ; Rösch, Paul:
Solution structure, dynamics, and hydrodynamics of the calcium-bound cross-reactive birch pollen allergen Bet v 4 reveal a canonical monomeric two EF-hand assembly with a regulatory function.
In: Journal of Molecular Biology. Vol. 336 (2004) Issue 5 . - pp. 1141-1157.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2003.12.070

Abstract in another language

Birch pollinosis is one of the prevailing allergic diseases. In all, 5–20% of birch pollinotics mount IgE antibodies against the minor birch pollen allergen Bet v 4, a Ca2+-binding polcalcin. Due to IgE cross-reactivity among the polcalcins these patients are polysensitized to various plant pollens. Determination of the high-resolution structure of holo Bet v 4 by heteronuclear NMR spectroscopy reveals a canonical two EF-hand assembly in the open conformation with interhelical angles closely resembling holo calmodulin. The polcalcin- ...

Further data

Item Type: Article in a journal
Refereed: Yes
Institutions of the University: Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biopolymers
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Biopolymers - Univ.-Prof. Dr. Paul Rösch
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biopolymers > Lehrstuhl Biopolymere - Apl. Prof. Dr. Birgitta Wöhrl
Profile Fields
Profile Fields > Advanced Fields
Profile Fields > Advanced Fields > Polymer and Colloid Science
Result of work at the UBT: Yes
DDC Subjects: 500 Science
500 Science > 500 Natural sciences
Date Deposited: 20 Mar 2015 08:21
Last Modified: 12 Jun 2019 08:37
URI: https://eref.uni-bayreuth.de/id/eprint/8596