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Antimicrobial Hydantoin-grafted Poly(ε-caprolactone) by Ring-opening Polymerization and Click Chemistry

Title data

Tan, Licheng ; Maji, Samarendra ; Mattheis, Claudia ; Chen, Yiwang ; Agarwal, Seema:
Antimicrobial Hydantoin-grafted Poly(ε-caprolactone) by Ring-opening Polymerization and Click Chemistry.
In: Macromolecular Bioscience. Vol. 12 (December 2012) Issue 12 . - pp. 1721-1730.
ISSN 1616-5187
DOI: https://doi.org/10.1002/mabi.201200238

Official URL: Volltext

Project information

Project financing: Deutsche Forschungsgemeinschaft

Abstract in another language

Novel degradable and antibacterial polycaprolactone-based polymers are reported in this work. The polyesters with pendent propargyl groups are successfully prepared by ring-opening polymerization and subsequently used to graft antibacterial hydantoin moieties via click chemistry by a copper(I)-catalyzed azide-alkyne cycloaddition reaction. The well-controlled chemical structures of the grafted copolymers and its precursors are verified by FT-IR spectroscopy, NMR spectroscopy, and GPC characterizations. According to the DSC and XRD results, the polymorphisms of these grafted copolymers are mostly changed from semicrystalline to amorphous depending on the amount of grafted hydantoin. Antibacterial assays are carried out with Bacillus subtilis and two strains of Escherichia coli and show fast antibacterial action.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: antibacterial; click chemistry; degradation; hydantoin; ring-opening polymerization
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Profile Fields > Advanced Fields > Polymer and Colloid Science
Research Institutions > Research Centres > Bayreuth Center for Colloids and Interfaces - BZKG
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Profile Fields
Profile Fields > Advanced Fields
Research Institutions
Research Institutions > Research Centres
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
500 Science > 570 Life sciences, biology
Date Deposited: 01 Apr 2015 11:21
Last Modified: 01 Apr 2015 11:21
URI: https://eref.uni-bayreuth.de/id/eprint/9784