Antimicrobial Hydantoin-grafted Poly(ε-caprolactone) by Ring-opening Polymerization and Click Chemistry

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Tan, Licheng ; Maji, Samarendra ; Mattheis, Claudia ; Chen, Yiwang ; Agarwal, Seema:
Antimicrobial Hydantoin-grafted Poly(ε-caprolactone) by Ring-opening Polymerization and Click Chemistry.
In: Macromolecular Bioscience. Bd. 12 (2012) Heft 12 . - S. 1721-1730.
ISSN 1616-5195
DOI: https://doi.org/10.1002/mabi.201200238

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Abstract

Novel degradable and antibacterial polycaprolactone-based polymers are reported in this work. The polyesters with pendent propargyl groups are successfully prepared by ring-opening polymerization and subsequently used to graft antibacterial hydantoin moieties via click chemistry by a copper(I)-catalyzed azide-alkyne cycloaddition reaction. The well-controlled chemical structures of the grafted copolymers and its precursors are verified by FT-IR spectroscopy, NMR spectroscopy, and GPC characterizations. According to the DSC and XRD results, the polymorphisms of these grafted copolymers are mostly changed from semicrystalline to amorphous depending on the amount of grafted hydantoin. Antibacterial assays are carried out with Bacillus subtilis and two strains of Escherichia coli and show fast antibacterial action.