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Functional Poly(Dimethyl Aminoethyl Methacrylate) by Combination of Radical Ring-Opening Polymerization and Click Chemistry for Biomedical Applications

Title data

Maji, Samarendra ; Mitschang, Fabian ; Chen, Lina ; Jin, Qiao ; Wang, Youxiang ; Agarwal, Seema:
Functional Poly(Dimethyl Aminoethyl Methacrylate) by Combination of Radical Ring-Opening Polymerization and Click Chemistry for Biomedical Applications.
In: Macromolecular Chemistry and Physics. Vol. 213 (28 August 2012) Issue 16 . - pp. 1643-1654.
ISSN 1521-3935
DOI: https://doi.org/10.1002/macp.201200220

Official URL: Volltext

Project information

Project financing: Alexander von Humboldt-Stiftung

Abstract in another language

In this work, the macromolecular design and modular synthesis of degradable and biocompatible copolymers via radical polymerization and click chemistry is highlighted and the resulting systems are evaluated as gene delivery carriers. Poly(ethylene glycol) (PEG) grafted poly2-methylene-1,3-dioxepane (MDO)-co-propargyl acrylate (PA)-co-2-(dimethyl aminoethyl methacrylate (DMAEMA) (MPD) is synthesized using radical polymerization and azide-alkyne click chemistry. The polymers are less cytotoxic and are able to condense plasmid DNA into nanosized particles. The low transfection efficiency of polyplexes in HepG2 cells is significantly improved by mixing Tat peptide with polyplexes.

Further data

Item Type: Article in a journal
Refereed: Yes
Keywords: click chemistry; cyclic ketene acetal; cytotoxicity; degradable polymers; transfection
Institutions of the University: Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner
Profile Fields > Advanced Fields > Polymer and Colloid Science
Research Institutions > Research Centres > Bayreuth Center for Colloids and Interfaces - BZKG
Faculties
Faculties > Faculty of Biology, Chemistry and Earth Sciences
Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry
Profile Fields
Profile Fields > Advanced Fields
Research Institutions
Research Institutions > Research Centres
Result of work at the UBT: No
DDC Subjects: 500 Science > 540 Chemistry
Date Deposited: 01 Apr 2015 12:18
Last Modified: 01 Apr 2015 12:18
URI: https://eref.uni-bayreuth.de/id/eprint/9789