Functional Poly(Dimethyl Aminoethyl Methacrylate) by Combination of Radical Ring-Opening Polymerization and Click Chemistry for Biomedical Applications

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Maji, Samarendra ; Mitschang, Fabian ; Chen, Lina ; Jin, Qiao ; Wang, Youxiang ; Agarwal, Seema:
Functional Poly(Dimethyl Aminoethyl Methacrylate) by Combination of Radical Ring-Opening Polymerization and Click Chemistry for Biomedical Applications.
In: Macromolecular Chemistry and Physics. Bd. 213 (2012) Heft 16 . - S. 1643-1654.
ISSN 1521-3935
DOI: https://doi.org/10.1002/macp.201200220

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Abstract

In this work, the macromolecular design and modular synthesis of degradable and biocompatible copolymers via radical polymerization and click chemistry is highlighted and the resulting systems are evaluated as gene delivery carriers. Poly(ethylene glycol) (PEG) grafted poly2-methylene-1,3-dioxepane (MDO)-co-propargyl acrylate (PA)-co-2-(dimethyl aminoethyl methacrylate (DMAEMA) (MPD) is synthesized using radical polymerization and azide-alkyne click chemistry. The polymers are less cytotoxic and are able to condense plasmid DNA into nanosized particles. The low transfection efficiency of polyplexes in HepG2 cells is significantly improved by mixing Tat peptide with polyplexes.