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Gebhardt, Klaus ; Schimana, Judith ; Krastel, Philipp ; Dettner, Konrad ; Rheinheimer, Joachim ; Zeeck, Axel ; Fiedler, Hans-Peter:
Endophenazines A-D, New Phenazine Antibiotics from the Arthropod Associated Endosymbiont Streptomyces anulatus.
In: The Journal of Antibiotics.
Bd. 55
(2002)
Heft 9
.
- S. 794-800.
ISSN 1881-1469
DOI: https://doi.org/10.7164/antibiotics.55.794
Abstract
Four new members of the phenazine family, endophenazines A~D, and the already known phenazine-1-carboxylic acid (tubermycin B) were detected in the culture broth of various endosymbiotic Streptomyces anulatus strains by chemical screening in a combination of TLC–staining reagents and HPLC–diode array analysis. The endosymbiotic strains were isolated from four different arthropod hosts at various sites. The new phenazine compounds showed antimicrobial activities against Gram-positive bacteria and some filamentous fungi, and herbicidal activity against Lemna minor (duckweed).