ERef Bayreuth

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Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering

Title data

Hardy, John G. ; Torres-Rendon, Jose Guillermo ; Leal-Egaña, Aldo ; Walther, Andreas ; Schlaad, Helmut ; Cölfen, Helmut ; Scheibel, Thomas:
Biomineralization of Engineered Spider Silk Protein-Based Composite Materials for Bone Tissue Engineering.
In: Materials. Vol. 9 (2016) Issue 7 . - 560.
ISSN 1996-1944
DOI: https://doi.org/10.3390/ma9070560

Abstract in another language

Materials based on biodegradable polyesters, such as poly(butylene terephthalate) (PBT)or poly(butylene terephthalate-co-poly(alkylene glycol) terephthalate) (PBTAT), have potential application as pro-regenerative scaffolds for bone tissue engineering. Herein, the preparation of films composed of PBT or PBTAT and an engineered spider silk protein, (eADF4(C16)),that displays multiple carboxylic acid moieties capable of binding calcium ions and facilitating their biomineralization with calcium carbonate or calcium phosphate is reported. Human mesenchymal stem cells cultured on films mineralized with calcium phosphate show enhanced levels of alkaline phosphatase activity suggesting that such composites have potential use for bone tissue engineering

Further data

Item Type:	Article in a journal
Refereed:	Yes
Keywords:	spider silk; recombinant protein; biodegradable polymers; biomaterials; biomineralization; bone tissue engineering
Institutions of the University:	Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel Profile Fields > Advanced Fields > Polymer and Colloid Science Profile Fields > Advanced Fields > Advanced Materials Profile Fields > Advanced Fields > Molecular Biosciences Profile Fields > Emerging Fields Profile Fields > Emerging Fields > Food and Health Sciences Research Institutions > Research Centres > Bayreuth Center for Material Science and Engineering - BayMAT Faculties Faculties > Faculty of Engineering Science Faculties > Faculty of Engineering Science > Chair Biomaterials Profile Fields Profile Fields > Advanced Fields Research Institutions Research Institutions > Research Centres
Result of work at the UBT:	Yes
DDC Subjects:	600 Technology, medicine, applied sciences 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited:	14 Jul 2016 07:30
Last Modified:	14 Feb 2023 13:16
URI:	https://eref.uni-bayreuth.de/id/eprint/33181