Recombinant Spider Silk–Silica Hybrid Scaffolds with Drug-Releasing Properties for Tissue Engineering Applications

Title data

Kumari, Sushma ; Bargel, Hendrik ; Scheibel, Thomas:
Recombinant Spider Silk–Silica Hybrid Scaffolds with Drug-Releasing Properties for Tissue Engineering Applications.
In: Macromolecular Rapid Communications. Vol. 41 (2020) Issue 1 . - 1900426.
ISSN 1521-3927
DOI: https://doi.org/10.1002/marc.201900426

Official URL:

Abstract in another language

Fabricating biomaterials with antimicrobial activity to prevent the growth of detrimental microorganisms is of great scientific and practical interest. Here, composite materials comprising recombinant spider silk proteins and mesoporous silica nanoparticles (MSN) loaded with selected antibiotics and antimycotics are fabricated into films and hydrogels. The derived composite materials exhibit excellent antimicrobial properties with sustained release of antibiotics over the course of 15 days. Furthermore, antibiotics/antimycotics inclusion does not impair the cytocompatibility of the composite materials, all of which promote fibroblast cell adhesion and proliferation. Finally, processing of spider silk–MSN composite hydrogels using 3D printing is shown to enable the fabrication of patient‐specific antimicrobial implants to prevent infection in the near future.

Further data

Item Type:	Article in a journal
Refereed:	Yes
Additional notes:	Special Issue: 100 Years of Macromolecular Chemistry. This article also appears in: Hot Topic: Mesoporous Materials
Institutions of the University:	Faculties Faculties > Faculty of Engineering Science Faculties > Faculty of Engineering Science > Chair Biomaterials Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel Profile Fields Profile Fields > Advanced Fields Profile Fields > Advanced Fields > Polymer and Colloid Science Profile Fields > Advanced Fields > Advanced Materials Profile Fields > Advanced Fields > Molecular Biosciences Profile Fields > Emerging Fields Profile Fields > Emerging Fields > Food and Health Sciences Research Institutions Research Institutions > Central research institutes Research Institutions > Central research institutes > Bayreuth Center for Material Science and Engineering - BayMAT
Result of work at the UBT:	Yes
DDC Subjects:	600 Technology, medicine, applied sciences 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited:	20 Jan 2020 12:19
Last Modified:	23 Aug 2023 07:56
URI:	https://eref.uni-bayreuth.de/id/eprint/54158