at Google ScholarTitle data
Balbach, Melanie ; Fushimi, Makoto ; Huggins, David J. ; Steegborn, Clemens ; Meinke, Peter T. ; Levin, Lonny R. ; Buck, Jochen:
Optimization of lead compounds into on-demand, nonhormonal contraceptives : leveraging a public-private drug discovery institute collaboration.
In: Biology of Reproduction.
Vol. 103
(2020)
Issue 2
.
- pp. 176-182.
ISSN 1529-7268
DOI: https://doi.org/10.1093/biolre/ioaa052
Abstract in another language
Efforts to develop new male or female nonhormonal, orally available contraceptives assume that to be effective and safe, targets must be (1) essential for fertility; (2) amenable to targeting by small-molecule inhibitors; and (3) restricted to the germline. In this perspective, we question the third assumption and propose that despite its wide expression, soluble adenylyl cyclase (sAC: ADCY10), which is essential for male fertility, is a valid target. We hypothesize that an acute-acting sAC inhibitor may provide orally available, on-demand, nonhormonal contraception for men without adverse, mechanism-based effects. To test this concept, we describe a collaboration between academia and the unique capabilities of a public-private drug discovery institute.
Further data
| Item Type: | Article in a journal |
|---|---|
| Refereed: | Yes |
| Keywords: | Apacitation; Male contraception; Soluble adenylyl cyclase |
| Institutions of the University: | Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry > Chair Biochemistry - Univ.-Prof. Dr. Clemens Steegborn Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Biochemistry |
| Result of work at the UBT: | No |
| DDC Subjects: | 500 Science > 540 Chemistry 500 Science > 570 Life sciences, biology |
| Date Deposited: | 07 Sep 2020 07:37 |
| Last Modified: | 22 Apr 2022 10:27 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/56810 |