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Recombinant Spider Silk Gels Derived from Aqueous–Organic Solvents as Depots for Drugs

Titelangaben

Neubauer, Vanessa J. ; Trossmann, Vanessa T. ; Jacobi, Sofia ; Döbl, Annika ; Scheibel, Thomas:
Recombinant Spider Silk Gels Derived from Aqueous–Organic Solvents as Depots for Drugs.
In: Angewandte Chemie International Edition. Bd. 60 (2021) Heft 21 . - S. 11847-11851.
ISSN 1521-3773
DOI: https://doi.org/10.1002/anie.202103147

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Projektfinanzierung: Deutsche Forschungsgemeinschaft

Abstract

Hydrogels are widely used in various biomedical applications, as they cannot only serve as materials for biofabrication but also as depots for the administration of drugs. However, the possibilities of formulation of water-insoluble drugs in hydrogels are rather limited. Herein, we assembled recombinant spider silk gels using a new processing route with aqueous–organic co-solvents, and the properties of these gels could be controlled by the choice of the co-solvent. The presence of the organic co-solvent further enabled the incorporation of hydrophobic drugs as exemplarily shown for 6-mercaptopurine. The developed gels showed shear-thinning behaviour and could be easily injected to serve, for example, as drug depots, and they could even be 3D printed to serve as scaffolds for biofabrication. With this new processing route, the formulation of water-insoluble drugs in spider silk-based depots is possible, circumventing common pharmaceutical solubility issues.

Weitere Angaben

Publikationsform: Artikel in einer Zeitschrift
Begutachteter Beitrag: Ja
Keywords: binary mixtures; co-solvent; hydrophobic effect; micro-heterogeneity; self-assembly
Institutionen der Universität: Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Biomaterialien > Lehrstuhl Biomaterialien - Univ.-Prof. Dr. Thomas Scheibel
Profilfelder > Advanced Fields
Profilfelder > Advanced Fields > Molekulare Biowissenschaften
Fakultäten
Fakultäten > Fakultät für Ingenieurwissenschaften
Fakultäten > Fakultät für Ingenieurwissenschaften > Lehrstuhl Biomaterialien
Profilfelder
Titel an der UBT entstanden: Ja
Themengebiete aus DDC: 600 Technik, Medizin, angewandte Wissenschaften > 600 Technik
600 Technik, Medizin, angewandte Wissenschaften > 620 Ingenieurwissenschaften
Eingestellt am: 04 Sep 2021 21:00
Letzte Änderung: 06 Sep 2021 05:43
URI: https://eref.uni-bayreuth.de/id/eprint/66922