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Maneira, Carla ; Chamas, Alexandre ; Lackner, Gerald:
Engineering Saccharomyces cerevisiae for medical applications.
In: Microbial Cell Factories.
Bd. 24
(2025)
.
- 12.
ISSN 1475-2859
DOI: https://doi.org/10.1186/s12934-024-02625-5
Abstract
Background
During the last decades, the advancements in synthetic biology opened the doors for a profusion of cost-effective, fast, and ecologically friendly medical applications priorly unimaginable. Following the trend, the genetic engineering of the baker’s yeast, Saccharomyces cerevisiae, propelled its status from an instrumental ally in the food industry to a therapy and prophylaxis aid.
Main text
In this review, we scrutinize the main applications of engineered S. cerevisiae in the medical field focusing on its use as a cell factory for pharmaceuticals and vaccines, a biosensor for diagnostic and biomimetic assays, and as a live biotherapeutic product for the smart in situ treatment of intestinal ailments. An extensive view of these fields' academic and commercial developments as well as main hindrances is presented.
Conclusion
Although the field still faces challenges, the development of yeast-based medical applications is often considered a success story. The rapid advances in synthetic biology strongly support the case for a future where engineered yeasts play an important role in medicine.
Weitere Angaben
| Publikationsform: | Artikel in einer Zeitschrift |
|---|---|
| Begutachteter Beitrag: | Ja |
| Keywords: | Saccharomyces cerevisiae; yeast; cell factory for pharmaceuticals and vaccines |
| Institutionen der Universität: | Fakultäten > Fakultät für Lebenswissenschaften: Lebensmittel, Ernährung und Gesundheit Fakultäten > Fakultät für Lebenswissenschaften: Lebensmittel, Ernährung und Gesundheit > Lehrstuhl Biochemie der Mikroorganismen > Lehrstuhl Biochemie der Mikroorganismen - Univ.-Prof. Dr. Gerald Lackner |
| Titel an der UBT entstanden: | Ja |
| Themengebiete aus DDC: | 500 Naturwissenschaften und Mathematik > 500 Naturwissenschaften 500 Naturwissenschaften und Mathematik > 540 Chemie 500 Naturwissenschaften und Mathematik > 570 Biowissenschaften; Biologie 600 Technik, Medizin, angewandte Wissenschaften 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin und Gesundheit |
| Eingestellt am: | 15 Jan 2025 08:19 |
| Letzte Änderung: | 15 Jan 2025 08:33 |
| URI: | https://eref.uni-bayreuth.de/id/eprint/91585 |