Design and proof of reversible micelle-to-vesicle multistimuli-responsive morphological regulations

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Jin, Qiao ; Luy, Christoph ; Ji, Jian ; Agarwal, Seema:
Design and proof of reversible micelle-to-vesicle multistimuli-responsive morphological regulations.
In: Journal of Polymer Science Part A: Polymer Chemistry. Bd. 50 (2012) Heft 3 . - S. 451-457.
ISSN 0360-6376
DOI: https://doi.org/10.1002/pola.25050

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Abstract

Multistimuli-responsive precise morphological control over self-assembled polymers is of great importance for applications in nanoscience as drug delivery system. A novel pH, photoresponsive, and cyclodextrin-responsive block copolymer were developed to investigate the reversible morphological transition from micelles to vesicles. The azobenzene-containing block copolymer poly(ethylene oxide)-b-poly(2-(diethylamino)ethyl methacrylate-co-6-(4-phenylazo phenoxy)hexyl methacrylate) PEO-b-P(DEAEMA-co-PPHMA) was synthesized by atom transfer radical polymerization. This system can self-assemble into vesicles in aqueous solution at pH 8. On adjusting the solution pH to 3, there was a transition from vesicles to micelles. The same behavior, that is, transition from vesicles to micelles was also realizable on addition of β-cyclodextrin (β-CD) to the PEO-b-P(DEAEMA-co-PPHMA) solution at pH 8. Furthermore, after β-CD was added, alternating irradiation of the solution with UV and visible light can also induce the reversible micelle-to-vesicle transition because of the photoinduced trans-to-cis isomerization of azobenzene units. The multistimuli-responsive precise morphological changes were studied by laser light scattering, transmission electron microscopy, and UV–vis spectra. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2011