Zeitschrift: Journal of Molecular Biology

2024

Xu, Qianzhao ; Vogt, Arend ; Frechen, Fabian ; Yi, Chengwei ; Küçükerden, Melike ; Ngum, Neville ; Sitjà-Roqueta, Laia ; Greiner, Andreas ; Parri, Rhein ; Masana, Mercè ; Wenger, Nikolaus ; Wachten, Dagmar ; Möglich, Andreas:
Engineering Bacteriophytochrome-coupled Photoactivated Adenylyl Cyclases for Enhanced Optogenetic cAMP Modulation.
In: Journal of Molecular Biology. Bd. 436 (2024) Heft 5 . - 168257.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2023.168257

2021

Dietler, Julia ; Schubert, Roman ; Krafft, Tobias G. A. ; Meiler, Simone ; Kainrath, Stephanie ; Richter, Florian ; Schweimer, Kristian ; Weyand, Michael ; Janovjak, Harald ; Möglich, Andreas:
A Light-Oxygen-Voltage Receptor Integrates Light and Temperature.
In: Journal of Molecular Biology. Bd. 433 (2021) Heft 15 . - 167107.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2021.167107

Romero-Romero, Sergio ; Costas, Miguel ; Silva Manzano, Daniel-Adriano ; Kordes, Sina ; Rojas-Ortega, Erendira ; Tapia, Cinthya ; Guerra, Yasel ; Shanmugaratnam, Sooruban ; Rodríguez-Romero, Adela ; Baker, David ; Höcker, Birte ; Fernández-Velasco, D. Alejandro:
The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach.
In: Journal of Molecular Biology. Bd. 433 (2021) Heft 18 . - 167153.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2021.167153

2020

Golonka, David ; Gerken, Uwe ; Köhler, Jürgen ; Möglich, Andreas:
The Association Kinetics Encode the Light Dependence of Arabidopsis Phytochrome B Interactions.
In: Journal of Molecular Biology. Bd. 432 (2020) Heft 16 . - S. 4327-4340.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2020.06.001

Ferruz, Noelia ; Lobos, Francisco ; Lemm, Dominik ; Toledo-Patiño, Saacnicteh ; Farías-Rico, José Arcadio ; Schmidt, Steffen ; Höcker, Birte:
Identification and Analysis of Natural Building Blocks for Evolution-Guided Fragment-Based Protein Design.
In: Journal of Molecular Biology. Bd. 432 (2020) Heft 13 . - S. 3898-3914.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2020.04.013

2019

Stabel, Robert ; Stüven, Birthe ; Hansen, Jan Niklas ; Körschen, Heinz G. ; Wachten, Dagmar ; Möglich, Andreas:
Revisiting and Redesigning Light-Activated Cyclic-Mononucleotide Phosphodiesterases.
In: Journal of Molecular Biology. Bd. 431 (2019) Heft 17 . - S. 3029-3045.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2019.07.011

2015

Schmid, Franz X.:
How proteins knot their ties.
In: Journal of Molecular Biology. Bd. 427 (2015) Heft 2 . - S. 225-227.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2014.10.018

2014

Hoffmann-Thoms, Stephanie ; Jakob, Roman P. ; Schmid, Franz X.:
Energetic communication between functional sites of the gene-3-protein during infection by phage fd.
In: Journal of Molecular Biology. Bd. 426 (2014) Heft 8 . - S. 1711-1722.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2014.01.002

Koch, Johanna R. ; Schmid, Franz X.:
Mia40 combines thiol oxidase and disulfide isomerase activity to efficiently catalyze oxidative folding in mitochondria.
In: Journal of Molecular Biology. Bd. 426 (2014) Heft 24 . - S. 4087-4098.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2014.10.022

Schmidpeter, Philipp A. M. ; Schmid, Franz X.:
Phosphorylation and prolyl isomerization independently regulate the signal adapter function of CrkII.
In: Journal of Molecular Biology. Bd. 426 (2014) Heft 24 . - S. 3929-3934.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2014.09.022

2013

Geitner, Anne-Juliane ; Varga, Edina ; Wehmer, Marc ; Schmid, Franz X.:
Generation of a highly active folding enzyme by combining a parvulin-type prolyl isomerase from SurA with an unrelated chaperone domain.
In: Journal of Molecular Biology. Bd. 425 (2013) Heft 22 . - S. 4089-4098.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2013.06.038

2012

Geitner, Anne-Juliane ; Schmid, Franz X.:
Combination of the human prolyl isomerase FKBP12 with unrelated chaperone domains leads to chimeric folding enzymes with high activity.
In: Journal of Molecular Biology. Bd. 420 (2012) Heft 4-5 . - S. 335-349.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2012.04.018

Topal, Hüsnü ; Fulcher, Nanette B. ; Bitterman, Jacob ; Salazar, Eric ; Buck, Jochen ; Levin, Lonny R. ; Cann, Martin J. ; Wolfgang, Matthew C. ; Steegborn, Clemens:
Crystal structure and regulation mechanisms of the CyaB adenylyl cyclase from the human pathogen Pseudomonas aeruginosa.
In: Journal of Molecular Biology. Bd. 416 (2012) Heft 2 . - S. 271-286.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2011.12.045

Ohlendorf, Robert ; Vidavski, Roee R. ; Eldar, Avigdor ; Moffat, Keith ; Möglich, Andreas:
From dusk till dawn : one-plasmid systems for light-regulated gene expression.
In: Journal of Molecular Biology. Bd. 416 (2012) Heft 4 . - S. 534-542.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2012.01.001

2011

Zoldák, Gabriel ; Schmid, Franz X.:
Cooperation of the prolyl isomerase and chaperone activities of the protein folding catalyst SlyD.
In: Journal of Molecular Biology. Bd. 406 (2011) Heft 1 . - S. 176-194.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2010.12.010

Lorenz, Stefan H. ; Jakob, Roman P. ; Weininger, Ulrich ; Balbach, Jochen ; Dobbek, Holger ; Schmid, Franz X.:
The filamentous phages fd and IF1 use different mechanisms to infect Escherichia coli.
In: Journal of Molecular Biology. Bd. 405 (2011) Heft 4 . - S. 989-1003.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2010.11.030

2010

Möglich, Andreas ; Ayers, Rebecca A. ; Moffat, Keith:
Addition at the molecular level : signal integration in designed Per-ARNT-Sim receptor proteins.
In: Journal of Molecular Biology. Bd. 400 (2010) Heft 3 . - S. 477-486.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2010.05.019

Spiegelhauer, Olivia ; Mende, Sophia ; Dickert, Frank ; Knauer, Stefan H. ; Ullmann, G. Matthias ; Dobbek, Holger:
Cysteine as a modulator residue in the active site of xenobiotic reductase A : a structural, thermodynamic and kinetic study.
In: Journal of Molecular Biology. Bd. 398 (2010) Heft 1 . - S. 66-82.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2010.02.044

Spiegelhauer, Olivia ; Werther, T. ; Mende, Sophia ; Knauer, Stefan H. ; Dobbek, Holger:
Determinants of Substrate Binding and Protonation in the Flavoenzyme Xenobiotic Reductase A.
In: Journal of Molecular Biology. Bd. 403 (2010) Heft 2 . - S. 286-298.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2010.08.047

Jakob, Roman P. ; Zierer, Bettina K. ; Weininger, Ulrich ; Hofmann, Stefanie D. ; Lorenz, Stefan H. ; Balbach, Jochen ; Dobbek, Holger ; Schmid, Franz X.:
Elimination of a cis-proline-containing loop and turn optimization stabilizes a protein and accelerates its folding.
In: Journal of Molecular Biology. Bd. 399 (2010) Heft 2 . - S. 331-346.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2010.04.007

2009

Zoldák, Gabriel ; Carstensen, Linn ; Scholz, Christian ; Schmid, Franz X.:
Consequences of domain insertion on the stability and folding mechanism of a protein.
In: Journal of Molecular Biology. Bd. 386 (2009) Heft 4 . - S. 1138-1152.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2008.12.052

Möglich, Andreas ; Ayers, Rebecca A. ; Moffat, Keith:
Design and signaling mechanism of light-regulated histidine kinases.
In: Journal of Molecular Biology. Bd. 385 (2009) Heft 5 . - S. 1433-1444.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2008.12.017

Thoms, Stephanie ; Max, Klaas E. A. ; Wunderlich, Michael ; Jacso, Tomas ; Lilie, Hauke ; Reif, Bernd ; Heinemann, Udo ; Schmid, Franz X.:
Dimer formation of a stabilized Gβ1 variant : a structural and energetic analysis.
In: Journal of Molecular Biology. Bd. 391 (2009) Heft 5 . - S. 918-932.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2009.06.031

Jakob, Roman P. ; Schmid, Franz X.:
Molecular determinants of a native-state prolyl isomerization.
In: Journal of Molecular Biology. Bd. 387 (2009) Heft 4 . - S. 1017-1031.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2009.02.021

Weininger, Ulrich ; Haupt, Caroline ; Schweimer, Kristian ; Graubner, Wenke ; Kovermann, Michael ; Brüser, Thomas ; Scholz, Christian ; Schaarschmidt, Peter ; Zoldák, Gabriel ; Schmid, Franz X. ; Balbach, Jochen:
NMR solution structure of SlyD from Escherichia coli : spatial separation of prolyl isomerase and chaperone function.
In: Journal of Molecular Biology. Bd. 387 (2009) Heft 2 . - S. 295-305.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2009.01.034

Schlicker, Christine ; Hall, Rebecca A. ; Vullo, Daniela ; Middelhaufe, Sabine ; Gertz, Melanie ; Supuran, Claudiu T. ; Mühlschlegel, Fritz A. ; Steegborn, Clemens:
Structure and inhibition of the CO₂-sensing carbonic anhydrase Can2 from the pathogenic fungus Cryptococcus neoformans.
In: Journal of Molecular Biology. Bd. 385 (2009) Heft 4 . - S. 1207-1220.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2008.11.037

Longen, Sebastian ; Bien, Melanie ; Bihlmaier, Karl ; Kloeppel, Christine ; Kauff, Frank ; Hammermeister, Miriam ; Westermann, Benedikt ; Herrmann, Johannes M. ; Riemer, Jan:
Systematic Analysis of the Twin Cx₉C Protein Family.
In: Journal of Molecular Biology. Bd. 393 (2009) Heft 2 . - S. 356-368.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2009.08.041

Mooney, Rachel A. ; Schweimer, Kristian ; Rösch, Paul ; Gottesman, Max E. ; Landick, Robert:
Two Structurally Independent Domains of E. coli NusG Create Regulatory Plasticity via Distinct Interactions with RNA Polymerase and Regulators.
In: Journal of Molecular Biology. Bd. 391 (2009) Heft 2 . - S. 341-358.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2009.05.078

2008

Kather, Insa ; Jakob, Roman P. ; Dobbek, Holger ; Schmid, Franz X.:
Changing the determinants of protein stability from covalent to non-covalent interactions by in vitro evolution : a structural and energetic analysis.
In: Journal of Molecular Biology. Bd. 381 (2008) Heft 4 . - S. 1040-1054.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2008.06.073

Jakob, Roman P. ; Schmid, Franz X.:
Energetic coupling between native-state prolyl isomerization and conformational protein folding.
In: Journal of Molecular Biology. Bd. 377 (2008) Heft 5 . - S. 1560-1575.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2008.02.010

Hennig, Janosch ; Bresell, Anders ; Sandberg, Martina ; Hennig, Klaus D. M. ; Wahren-Herlenius, Marie ; Persson, Bengt ; Sunnerhagen, Maria:
The Fellowship of the RING : The RING–B-Box Linker Region Interacts with the RING in TRIM21/Ro52, Contains a Native Autoantigenic Epitope in Sjögren Syndrome, and is an Integral and Conserved Region in TRIM Proteins.
In: Journal of Molecular Biology. Bd. 377 (2008) Heft 2 . - S. 431-449.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2008.01.005

Kather, Insa ; Jakob, Roman P. ; Dobbek, Holger ; Schmid, Franz X.:
Increased Folding Stability of TEM-1 β-Lactamase by In Vitro Selection.
In: Journal of Molecular Biology. Bd. 383 (2008) Heft 1 . - S. 238-251.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2008.07.082

Hartl, Maximilian J. ; Wöhrl, Birgitta M. ; Rösch, Paul ; Schweimer, Kristian:
The Solution Structure of the Simian Foamy Virus Protease Reveals a Monomeric Protein.
In: Journal of Molecular Biology. Bd. 381 (2008) Heft 1 . - S. 141-149.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2008.05.064

Schlicker, Christine ; Gertz, Melanie ; Papatheodorou, Panagiotis ; Kachholz, Barbara ; Becker, Christian F. W. ; Steegborn, Clemens:
Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5.
In: Journal of Molecular Biology. Bd. 382 (2008) Heft 3 . - S. 790-801.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2008.07.048

2007

Eckert, Barbara ; Schmid, Franz X.:
A conformational unfolding reaction activates phage fd for the infection of Escherichia coli.
In: Journal of Molecular Biology. Bd. 373 (2007) Heft 2 . - S. 452-461.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2007.07.060

Löw, Christian ; Weininger, Ulrich ; Zeeb, Markus ; Zhang, Wei ; Laue, Ernest D. ; Schmid, Franz X. ; Balbach, Jochen:
Folding mechanism of an ankyrin repeat protein : scaffold and active site formation of human CDK inhibitor p19(INK4d).
In: Journal of Molecular Biology. Bd. 373 (2007) Heft 1 . - S. 219-231.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2007.07.063

Knappe, Thomas A. ; Eckert, Barbara ; Schaarschmidt, Peter ; Scholz, Christian ; Schmid, Franz X.:
Insertion of a chaperone domain converts FKBP12 into a powerful catalyst of protein folding.
In: Journal of Molecular Biology. Bd. 368 (2007) Heft 5 . - S. 1458-1468.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2007.02.097

Mannherz, Hans Georg ; Ballweber, Edda ; Galla, Marco ; Villard, Sylvie ; Granier, Claude ; Steegborn, Clemens ; Schmidtmann, Anja ; Jaquet, Kornelia ; Pope, Brian ; Weeds, Alan G.:
Mapping the ADF/cofilin binding site on monomeric actin by competitive cross-linking and peptide array : evidence for a second binding site on monomeric actin.
In: Journal of Molecular Biology. Bd. 366 (2007) Heft 3 . - S. 745-755.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2006.11.100

Wunderlich, Michael ; Max, Klaas E. A. ; Roske, Yvette ; Mueller, Uwe ; Heinemann, Udo ; Schmid, Franz X.:
Optimization of the Gβ1 domain by computational design and by in vitro evolution: structural and energetic basis of stabilization.
In: Journal of Molecular Biology. Bd. 373 (2007) Heft 3 . - S. 775-784.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2007.08.004

Max, Klaas E. A. ; Wunderlich, Michael ; Roske, Yvette ; Schmid, Franz X. ; Heinemann, Udo:
Optimized variants of the cold shock protein from in vitro selection : structural basis of their high thermostability.
In: Journal of Molecular Biology. Bd. 369 (2007) Heft 4 . - S. 1087-1097.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2007.04.016

Sanjuán Szklarz, Luiza K. ; Kozjak-Pavlovic, Vera ; Vögtle, F.-Nora ; Chacinska, Agnieszka ; Milenkovic, Dusanka ; Vogel, Sandra ; Dürr, Mark ; Westermann, Benedikt ; Guiard, Bernard ; Martinou, Jean-Claude ; Borner, Christoph ; Pfanner, Nikolaus ; Meisinger, Chris:
Preprotein Transport Machineries of Yeast Mitochondrial Outer Membrane Are not Required for Bax-induced Release of Intermembrane Space Proteins.
In: Journal of Molecular Biology. Bd. 368 (2007) Heft 1 . - S. 44-54.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2007.01.016

Möglich, Andreas ; Moffat, Keith:
Structural basis for light-dependent signaling in the dimeric LOV domain of the photosensor YtvA.
In: Journal of Molecular Biology. Bd. 373 (2007) Heft 1 . - S. 112-126.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2007.07.039

2006

Wunderlich, Michael ; Schmid, Franz X.:
In vitro evolution of a hyperstable Gbeta1 variant.
In: Journal of Molecular Biology. Bd. 363 (2006) Heft 2 . - S. 545-557.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2006.08.034

Garcia-Mira, Maria M. ; Schmid, Franz X.:
Key role of coulombic interactions for the folding transition state of the cold shock protein.
In: Journal of Molecular Biology. Bd. 364 (2006) Heft 3 . - S. 458-468.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2006.08.071

Kamenetsky, Margarita ; Middelhaufe, Sabine ; Bank, Erin M. ; Levin, Lonny R. ; Buck, Jochen ; Steegborn, Clemens:
Molecular details of cAMP generation in mammalian cells : a tale of two systems.
In: Journal of Molecular Biology. Bd. 362 (2006) Heft 4 . - S. 623-639.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2006.07.045

Magg, Christine ; Kubelka, Jan ; Holtermann, Georg ; Haas, Elisha ; Schmid, Franz X.:
Specificity of the initial collapse in the folding of the cold shock protein.
In: Journal of Molecular Biology. Bd. 360 (2006) Heft 5 . - S. 1067-1080.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2006.05.073

Griese, Julia J. ; Jakob, Roman P. ; Schwarzinger, Stephan ; Dobbek, Holger:
Xenobiotic Reductase A in the Degradation of Quinoline by Pseudomonas putida 86.
In: Journal of Molecular Biology. Bd. 361 (2006) Heft 1 . - S. 140-152.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2006.06.007

2005

Wunderlich, Michael ; Martin, Andreas ; Staab, Claudia A. ; Schmid, Franz X.:
Evolutionary protein stabilization in comparison with computational design.
In: Journal of Molecular Biology. Bd. 351 (2005) Heft 5 . - S. 1160-1168.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2005.06.059

Scholz, Christian ; Schaarschmidt, Peter ; Engel, Alfred M. ; Andres, Herbert ; Schmitt, Urban ; Faatz, Elke ; Balbach, Jochen ; Schmid, Franz X.:
Functional solubilization of aggregation-prone HIV envelope proteins by covalent fusion with chaperone modules.
In: Journal of Molecular Biology. Bd. 345 (2005) Heft 5 . - S. 1229-1241.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2004.10.091

Möglich, Andreas ; Krieger, Florian ; Kiefhaber, Thomas:
Molecular basis for the effect of urea and guanidinium chloride on the dynamics of unfolded polypeptide chains.
In: Journal of Molecular Biology. Bd. 345 (2005) Heft 1 . - S. 153-162.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2004.10.036

Wunderlich, Michael ; Martin, Andreas ; Schmid, Franz X.:
Stabilization of the cold shock protein CspB from Bacillus subtilis by evolutionary optimization of Coulombic interactions.
In: Journal of Molecular Biology. Bd. 347 (2005) Heft 5 . - S. 1063-1076.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2005.02.014

Kather, Insa ; Bippes, Christian A. ; Schmid, Franz X.:
A stable disulfide-free gene-3-protein of phage fd generated by in vitro evolution.
In: Journal of Molecular Biology. Bd. 354 (2005) Heft 3 . - S. 666-678.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2005.09.086

2004

Martin, Georges ; Möglich, Andreas ; Keller, Walter ; Doublié, Sylvie:
Biochemical and structural insights into substrate binding and catalytic mechanism of mammalian poly(A) polymerase.
In: Journal of Molecular Biology. Bd. 341 (2004) Heft 4 . - S. 911-925.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2004.06.047

Garcia-Mira, Maria M. ; Boehringer, Daniel ; Schmid, Franz X.:
The folding transition state of the cold shock protein is strongly polarized.
In: Journal of Molecular Biology. Bd. 339 (2004) Heft 3 . - S. 555-569.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2004.04.011

Magg, Christine ; Schmid, Franz X.:
Rapid collapse precedes the fast two-state folding of the cold shock protein.
In: Journal of Molecular Biology. Bd. 335 (2004) Heft 5 . - S. 1309-1323.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2003.11.050

Neudecker, Philipp ; Nerkamp, Jörg ; Eisenmann, Anke ; Nourse, Amanda ; Lauber, Thomas ; Schweimer, Kristian ; Lehmann, Katrin ; Schwarzinger, Stephan ; Ferreira, Fátima ; Rösch, Paul:
Solution structure, dynamics, and hydrodynamics of the calcium-bound cross-reactive birch pollen allergen Bet v 4 reveal a canonical monomeric two EF-hand assembly with a regulatory function.
In: Journal of Molecular Biology. Bd. 336 (2004) Heft 5 . - S. 1141-1157.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2003.12.070

Güthe, Sarah ; Kapinos, Larisa ; Möglich, Andreas ; Meier, Sebastian ; Grzesiek, Stephan ; Kiefhaber, Thomas:
Very fast folding and association of a trimerization domain from bacteriophage T4 fibritin.
In: Journal of Molecular Biology. Bd. 337 (2004) Heft 4 . - S. 905-915.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2004.02.020

2003

Marković-Housley, Zora ; Degano, Massimo ; Lamba, Doriano ; von Roepenack-Lahaye, Edda ; Clemens, Stephan ; Susani, Markus ; Ferreira, Fátima ; Scheiner, Otto ; Breiteneder, Heimo:
Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier.
In: Journal of Molecular Biology. Bd. 325 (2003) Heft 1 . - S. 123-133.
ISSN 0022-2836
DOI: https://doi.org/10.1016/S0022-2836(02)01197-X

Augustin, Martin A. ; Reichert, Andreas S. ; Betat, Heike ; Huber, Robert ; Mörl, Mario ; Steegborn, Clemens:
Crystal structure of the human CCA-adding enzyme: insights into template-independent polymerization.
In: Journal of Molecular Biology. Bd. 328 (2003) Heft 5 . - S. 985-994.
ISSN 0022-2836
DOI: https://doi.org/10.1016/S0022-2836(03)00381-4

Martin, Andreas ; Schmid, Franz X.:
Evolutionary stabilization of the gene-3-protein of phage fd reveals the principles that govern the thermodynamic stability of two-domain proteins.
In: Journal of Molecular Biology. Bd. 328 (2003) Heft 4 . - S. 863-875.
ISSN 0022-2836
DOI: https://doi.org/10.1016/S0022-2836(03)00359-0

Martin, Andreas ; Schmid, Franz X.:
The folding mechanism of a two-domain protein : folding kinetics and domain docking of the gene-3 protein of phage fd.
In: Journal of Molecular Biology. Bd. 329 (2003) Heft 3 . - S. 599-610.
ISSN 0022-2836
DOI: https://doi.org/10.1016/S0022-2836(03)00433-9

Lauber, Thomas ; Schulz, Axel ; Schweimer, Kristian ; Adermann, Knut ; Marx, Ute C.:
Homologous Proteins with Different Folds : The Three-Dimensional Structures of Domains 1 and 6 of the Multiple Kazal-Type Inhibitor LEKTI.
In: Journal of Molecular Biology. Bd. 328 (2003) Heft 1 . - S. 205-219.
ISSN 0022-2836
DOI: https://doi.org/10.1016/S0022-2836(03)00245-6

Maier, Raimund ; Eckert, Barbara ; Scholz, Christian ; Lilie, Hauke ; Schmid, Franz X.:
Interaction of trigger factor with the ribosome.
In: Journal of Molecular Biology. Bd. 326 (2003) Heft 2 . - S. 585-592.
ISSN 0022-2836
DOI: https://doi.org/10.1016/S0022-2836(02)01427-4

Martin, Andreas ; Schmid, Franz X.:
A proline switch controls folding and domain interactions in the gene-3-protein of the filamentous phage fd.
In: Journal of Molecular Biology. Bd. 331 (2003) Heft 5 . - S. 1131-1140.
ISSN 0022-2836
DOI: https://doi.org/10.1016/S0022-2836(03)00864-7

2002

Dominy, Brian N. ; Perl, Dieter ; Schmid, Franz X. ; Brooks, Charles L.:
The effects of ionic strength on protein stability : the cold shock protein family.
In: Journal of Molecular Biology. Bd. 319 (2002) Heft 2 . - S. 541-554.
ISSN 0022-2836
DOI: https://doi.org/10.1016/S0022-2836(02)00259-0

Martin, Andreas ; Kather, Insa ; Schmid, Franz X.:
Origins of the high stability of an in vitro-selected cold-shock protein.
In: Journal of Molecular Biology. Bd. 318 (2002) Heft 5 . - S. 1341-1349.
ISSN 0022-2836
DOI: https://doi.org/10.1016/S0022-2836(02)00243-7

Jacob, Maik H. ; Saudan, Christophe ; Holtermann, Georg ; Martin, Andreas ; Perl, Dieter ; Merbach, André E. ; Schmid, Franz X.:
Water contributes actively to the rapid crossing of a protein unfolding barrier.
In: Journal of Molecular Biology. Bd. 318 (2002) Heft 3 . - S. 837-845.
ISSN 0022-2836
DOI: https://doi.org/10.1016/S0022-2836(02)00165-1

2001

Steegborn, Clemens ; Laber, Bernd ; Messerschmidt, Albrecht ; Huber, Robert ; Clausen, Tim:
Crystal structures of cystathionine γ-synthase inhibitor complexes rationalize the increased affinity of a novel inhibitor.
In: Journal of Molecular Biology. Bd. 311 (2001) Heft 4 . - S. 789-801.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.2001.4880

Delbrück, Heinrich ; Mueller, Uwe ; Perl, Dieter ; Schmid, Franz X. ; Heinemann, Udo:
Crystal structures of mutant forms of the Bacillus caldolyticus cold shock protein differing in thermal stability.
In: Journal of Molecular Biology. Bd. 313 (2001) Heft 2 . - S. 359-369.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.2001.5051

Maier, Raimund ; Scholz, Christian ; Schmid, Franz X.:
Dynamic association of trigger factor with protein substrates.
In: Journal of Molecular Biology. Bd. 314 (2001) Heft 5 . - S. 1181-1190.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.2000.5192

Perl, Dieter ; Schmid, Franz X.:
Electrostatic stabilization of a thermophilic cold shock protein.
In: Journal of Molecular Biology. Bd. 313 (2001) Heft 2 . - S. 343-357.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.2001.5050

Martin, Andreas ; Sieber, Volker ; Schmid, Franz X.:
In-vitro selection of highly stabilized protein variants with optimized surface.
In: Journal of Molecular Biology. Bd. 309 (2001) Heft 3 . - S. 717-726.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.2001.4698

Lutz, Thomas ; Westermann, Benedikt ; Neupert, Walter ; Herrmann, Johannes M.:
The mitochondrial proteins Ssq1 and Jac1 are required for the assembly of iron sulfur clusters in mitochondria.
In: Journal of Molecular Biology. Bd. 307 (2001) Heft 3 . - S. 815-825.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.2001.4527

2000

Kensch, Oliver ; Restle, Tobias ; Wöhrl, Birgitta M. ; Goody, Roger S. ; Steinhoff, Heinz-Jürgen:
Temperature-dependent equilibrium between the open and closed conformation of the p66 subunit of the HIV-1 reverse transcriptase revealed by site-directed spin labelling.
In: Journal of Molecular Biology. Bd. 301 (2000) Heft 4 . - S. 1029-1039.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.2000.3998

Mueller, Uwe ; Perl, Dieter ; Schmid, Franz X. ; Heinemann, Udo:
Thermal stability and atomic-resolution crystal structure of the Bacillus caldolyticus cold shock protein.
In: Journal of Molecular Biology. Bd. 297 (2000) Heft 4 . - S. 975-988.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.2000.3602

1999

Steegborn, Clemens ; Messerschmidt, Albrecht ; Laber, Bernd ; Streber, Wolfgang ; Huber, Robert ; Clausen, Tim:
The crystal structure of cystathionine γ-synthase from Nicotiana tabacum reveals its substrate and reaction specificity.
In: Journal of Molecular Biology. Bd. 290 (1999) Heft 5 . - S. 983-996.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.1999.2935

Balbach, Jochen ; Steegborn, Clemens ; Schindler, Thomas ; Schmid, Franz X.:
A protein folding intermediate of ribonuclease T₁ characterized at high resolution by 1D and 2D real-time NMR spectroscopy.
In: Journal of Molecular Biology. Bd. 285 (1999) Heft 2 . - S. 829-842.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.1998.2364

Wöhrl, Birgitta M. ; Krebs, Ruth ; Goody, Roger S. ; Restle, Tobias:
Refined model for primer/template binding by HIV-1 reverse transcriptase : pre-steady-state kinetic analyses of primer/template binding and nucleotide incorporation events distinguish between different binding modes depending on the nature of the nucleic acid substrate.
In: Journal of Molecular Biology. Bd. 292 (1999) Heft 2 . - S. 333-344.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.1999.3057

1998

Willbold, Dieter ; Metzger, Armin U. ; Sticht, Heinrich ; Gallert, Karl-Christian ; Voit, Renate ; Dank, Norbert ; Bayer, Peter ; Krauss, Gerhard ; Goody, Roger S. ; Rösch, Paul:
Equine Infectious Anemia Virus Transactivator is a Homeodomain-Type protein.
In: Journal of Molecular Biology. Bd. 277 (1998) Heft 4 . - S. 749-755.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.1998.1636

Nichtl, Alfons ; Buchner, Johannes ; Jaenicke, Rainer ; Rudolph, Rainer ; Scheibel, Thomas:
Folding and association of β-galactosidase.
In: Journal of Molecular Biology. Bd. 282 (1998) Heft 5 . - S. 1083-1091.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.1998.2075

Sticht, Heinrich ; Pickford, Andrew R. ; Potts, Jennifer R. ; Campbell, Iain D.:
Solution structure of the glycosylated second type 2 module of fibronectin.
In: Journal of Molecular Biology. Bd. 276 (1998) Heft 1 . - S. 177-187.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.1997.1528

1997

Westermann, Benedikt ; Neupert, Walter:
Mdj2p, a novel DnaJ homolog in the mitochondrial inner membrane of the yeast Saccharomyces cerevisiae.
In: Journal of Molecular Biology. Bd. 272 (1997) Heft 4 . - S. 477-483.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.1997.1267

Zarnt, Toralf ; Tradler, Thomas ; Stoller, Gerlind ; Scholz, Christian ; Schmid, Franz X. ; Fischer, Gunter:
Modular structure of the trigger factor required for high activity in protein folding.
In: Journal of Molecular Biology. Bd. 271 (1997) Heft 5 . - S. 827-837.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.1997.1206

1996

Rausch, Jason W. ; Arts, Eric J. ; Wöhrl, Birgitta M. ; Le Grice, Stuart F.J.:
Involvement of C-terminal structural elements of Equine Infectious Anemia Virus reverse transcriptase in DNA polymerase and ribonuclease H activities.
In: Journal of Molecular Biology. Bd. 257 (1996) Heft 3 . - S. 500-511.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.1996.0181

1995

Walter, Stefan ; Hubner, Bernd ; Hahn, Ulrich ; Schmid, Franz X.:
Destabilization of a protein helix by electrostatic interactions.
In: Journal of Molecular Biology. Bd. 252 (1995) Heft 1 . - S. 133-143.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.1995.0480

Frech, Christian ; Schmid, Franz X.:
Influence of protein conformation on disulfide bond formation in the oxidative folding of ribonuclease T₁.
In: Journal of Molecular Biology. Bd. 251 (1995) Heft 1 . - S. 135-149.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.1995.0421

Odefey, C. ; Mayr, Lorenz M. ; Schmid, Franz X.:
Non-prolyl cis-trans peptide bond isomerization as a rate-determining step in protein unfolding and refolding.
In: Journal of Molecular Biology. Bd. 245 (1995) Heft 1 . - S. 69-78.
ISSN 0022-2836
DOI: https://doi.org/10.1016/S0022-2836(95)80039-5

Bayer, Peter ; Kraft, Margot ; Ejchart, Andrzej ; Westendorp, Michael ; Frank, Rainer ; Rösch, Paul:
Structural Studies of HIV-1 Tat Protein.
In: Journal of Molecular Biology. Bd. 247 (1995) Heft 4 . - S. 529-535.
ISSN 0022-2836
DOI: https://doi.org/10.1016/S0022-2836(05)80133-0

1994

Mayr, Lorenz M. ; Willbold, Dieter ; Rösch, Paul ; Schmid, Franz X.:
Generation of a non-prolyl cis peptide bond in ribonuclease T1.
In: Journal of Molecular Biology. Bd. 240 (1994) Heft 4 . - S. 288-293.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.1994.1446

Mücke, Matthias ; Schmid, Franz X.:
Intact disulfide bonds decelerate the folding of ribonuclease T1.
In: Journal of Molecular Biology. Bd. 239 (1994) Heft 5 . - S. 713-725.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.1994.1408

1993

Mayr, Lorenz M. ; Schmid, Franz X.:
Kinetic models for unfolding and refolding of ribonuclease T₁ with substitution of cis-proline 39 by alanine.
In: Journal of Molecular Biology. Bd. 231 (1993) Heft 3 . - S. 913-926.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.1993.1337

Mayr, Lorenz M. ; Landt, Olfert ; Hahn, Ulrich ; Schmid, Franz X.:
Stability and folding kinetics of ribonuclease T₁ are strongly altered by the replacement of cis-proline 39 with alanine.
In: Journal of Molecular Biology. Bd. 231 (1993) Heft 3 . - S. 897-912.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.1993.1336

1992

Kiefhaber, Thomas ; Kohler, Hans-Helmut ; Schmid, Franz X.:
Kinetic coupling between protein folding and prolyl isomerization. I. Theoretical models.
In: Journal of Molecular Biology. Bd. 224 (1992) Heft 1 . - S. 217-229.
ISSN 0022-2836
DOI: https://doi.org/10.1016/0022-2836(92)90585-8

Kiefhaber, Thomas ; Schmid, Franz X.:
Kinetic coupling between protein folding and prolyl isomerization. II. Folding of ribonuclease A and ribonuclease T₁.
In: Journal of Molecular Biology. Bd. 224 (1992) Heft 1 . - S. 231-240.
ISSN 0022-2836
DOI: https://doi.org/10.1016/0022-2836(92)90586-9

1991

Wöhrl, Birgitta M. ; Volkmann, Silke ; Moelling, Karin:
Mutations of a conserved residue within HIV-1 ribonuclease H affect its exo- and endonuclease activities.
In: Journal of Molecular Biology. Bd. 220 (1991) Heft 3 . - S. 801-818.
ISSN 0022-2836
DOI: https://doi.org/10.1016/0022-2836(91)90119-Q

1990

Lang, Kurt ; Schmid, Franz X.:
Role of two proline-containing turns in the folding of porcine ribonuclease.
In: Journal of Molecular Biology. Bd. 212 (1990) Heft 1 . - S. 185-196.
ISSN 0022-2836
DOI: https://doi.org/10.1016/0022-2836(90)90314-C

1986

Grafl, Reinhard ; Lang, Kurt ; Wrba, Alex ; Schmid, Franz X.:
Folding mechanism of porcine ribonuclease.
In: Journal of Molecular Biology. Bd. 191 (1986) Heft 2 . - S. 281-293.
ISSN 0022-2836
DOI: https://doi.org/10.1016/0022-2836(86)90265-2

1983

Krebs, Herbert ; Schmid, Franz X. ; Jaenicke, Rainer:
Folding of homologous proteinsm : The refolding of different ribonucleases is independent of sequence variations, proline content and glycosylation.
In: Journal of Molecular Biology. Bd. 169 (1983) Heft 2 . - S. 619-635.
ISSN 0022-2836
DOI: https://doi.org/10.1016/S0022-2836(83)80067-9

1979

Schmid, Franz X. ; Baldwin, Robert L.:
Detection of an early intermediate in the folding of ribonuclease A by protection of amide protons against exchange.
In: Journal of Molecular Biology. Bd. 135 (1979) Heft 1 . - S. 199-215.
ISSN 0022-2836
DOI: https://doi.org/10.1016/0022-2836(79)90347-4

Schmid, Franz X. ; Baldwin, Robert L.:
The rate of interconversion between the two unfolded forms of ribonuclease A does not depend on guanidinium chloride concentration.
In: Journal of Molecular Biology. Bd. 133 (1979) Heft 2 . - S. 285-287.
ISSN 0022-2836
DOI: https://doi.org/10.1016/0022-2836(79)90536-9