LCST and UCST in one : Double thermoresponsive behavior of block copolymers of poly(ethylene glycol) and poly(acrylamide-co-acrylonitrile)

Title data

Käfer, Florian ; Liu, Fangyao ; Stahlschmidt, Ullrich ; Jérôme, Valérie ; Freitag, Ruth ; Karg, Matthias ; Agarwal, Seema:
LCST and UCST in one : Double thermoresponsive behavior of block copolymers of poly(ethylene glycol) and poly(acrylamide-co-acrylonitrile).
In: Langmuir. Vol. 31 (2015) Issue 32 . - pp. 8940-8946.
ISSN 1520-5827
DOI: https://doi.org/10.1021/acs.langmuir.5b02006

Official URL:

Abstract in another language

The change in thermoresponsive behavior from a single phase transition of UCST-type of an acrylamide-acrylonitrile copolymer (AAm-co-AN) to a double responsive behavior (LCST-UCST-type) in water by the introduction of a poly(ethylene glycol) (PEG) block is highlighted in the present work. The polymer is synthesized in a simple way by free-radical polymerization of acrylamide and acrylonitrile using a poly(ethylene glycol) (PEG) macro-azoinitiator. The dual thermoresponsive behavior was observed in a wide range of concentration repeatable for many cycles with very small hysteresis. Static light scattering (SLS) and dynamic light scattering (DLS) together with turbidity photometry and transmission electron microscopy confirmed a unique phase transition behavior due to the temperature dependent change in the morphology from micelles to agglomerates and back to micelles. The low cytotoxicity and two-in-one thermoresponsive behavior makes the polymer promising for biomedical applications in the future.

Further data

Item Type:	Article in a journal
Refereed:	Yes
Additional notes:	PMID: 26202833
Institutions of the University:	Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Physical Chemistry I Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Chair Physical Chemistry I - Univ.-Prof. Dr. Stephan Förster Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry II > Chair Macromolecular Chemistry II - Univ.-Prof. Dr. Andreas Greiner Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Former Professors > Junior Professor Colloidal Systems - Juniorprof. Dr. Matthias Karg Faculties > Faculty of Engineering Science Faculties > Faculty of Engineering Science > Chair Process Biotechnology Faculties > Faculty of Engineering Science > Chair Process Biotechnology > Chair Process Biotechnology - Univ.-Prof. Dr. Ruth Freitag Profile Fields Profile Fields > Advanced Fields Profile Fields > Advanced Fields > Polymer and Colloid Science Research Institutions Research Institutions > Research Centres Research Institutions > Research Centres > Bayreuth Institute of Macromolecular Research - BIMF Research Institutions > Research Centres > Bayreuth Center for Colloids and Interfaces - BZKG
Result of work at the UBT:	Yes
DDC Subjects:	500 Science > 500 Natural sciences 500 Science > 540 Chemistry 600 Technology, medicine, applied sciences > 620 Engineering
Date Deposited:	27 Jul 2015 08:22
Last Modified:	14 Mar 2023 06:56
URI:	https://eref.uni-bayreuth.de/id/eprint/17181