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Golser, Adrian V. ; Röber, Matthias ; Börner, Hans G. ; Scheibel, Thomas:
Engineered Collagen : A Redox Switchable Framework for Tunable Assembly and Fabrication of Biocompatible Surfaces.
In: ACS Biomaterials Science & Engineering.
Bd. 4
(2018)
Heft 6
.
- S. 2106-2114.
ISSN 2373-9878
DOI: https://doi.org/10.1021/acsbiomaterials.7b00583
Abstract
Collagen, processed into several morphologies and riginating from various sources, has long since been used as a biocompatible material that can assist wound healing and tissue regeneration. With the advent of biotechnology and solid-phase peptide synthesis, new possibilities arise to create rationally designed biomaterials based on collagen sequences incorporating new functionalities while maintaining the beneficial properties of natural collagen. In this study a new class of synthetic collagen materials is presented,defined by its simplistic core structure and its therefore predictable behavior. These so-called eCols (engineered collagens) consist of a varying number of Gly-Pro-Pro repeats, a redox-switchable aminoterminal nucleation site and an optional carboxyterminal cell adhesion motif. We show which of these proteins are able to self-assemble into triple helices and cross-linked gelatinous networks and provide insights into their cytocompatibility in vitro.