bei Google ScholarTitelangaben
Neubauer, Vanessa J. ; Döbl, Annika ; Scheibel, Thomas:
Silk-Based Materials for Hard Tissue Engineering.
In: Materials.
Bd. 14
(2021)
Heft 3
.
- 674.
ISSN 1996-1944
DOI: https://doi.org/10.3390/ma14030674
Abstract
Hard tissues, e.g., bone, are mechanically stiff and, most typically, mineralized. To design scaffolds for hard tissue regeneration, mechanical, physico-chemical and biological cues must align with those found in the natural tissue.Combiningthese aspects poses challenges for material and construct design. Silk-based materials are promising for bone tissue regeneration as they fulfill several of such necessary requirements, and they are non-toxic and biodegradable. They can be processed into a variety of morphologies such as hydrogels, particles and fibers and can be mineralized. Therefore, silk-based materials are versatile candidates for biomedical applications in the field of hard tissue engineering. This review summarizes silk-based approaches for mineralized tissue replacements, and how to find the balance between sufficient material stiffness upon mineralization and cell survival upon attachment as well as nutrient supply.