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Pristine and artificially-aged polystyrene microplastic particles differ in
regard to cellular response
Title data
Völkl, Matthias ; Jérôme, Valérie ; Weig, Alfons ; Jasinski, Julia ; Meides, Nora ; Strohriegl, Peter ; Scheibel, Thomas ; Freitag, Ruth:
Pristine and artificially-aged polystyrene microplastic particles differ in
regard to cellular response.
In: Journal of Hazardous Materials.
Vol. 435
(2022)
.
- 128955.
ISSN 0304-3894
DOI: https://doi.org/10.1016/j.jhazmat.2022.128955
Official URL:
Project information
Project financing: |
Deutsche Forschungsgemeinschaft
SFB 1357 – 391977956
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Abstract in another language
Microplastic particles (MP), arising from the gradual decomposition of plastics in the environment, have been identified as a global problem. Most investigations of MP cytotoxicity use pristine spherical particles available from commercial sources when evaluating their impact on mammalian cells, while only limited data is available for the more relevant “weathered microplastic”. In this study, we exposed murine macrophages to polystyrene MP either after up to 130 days of accelerated ageing or in pristine condition. Weathered and pristine MP were physicochemically characterized, and their cytotoxicity was investigated using biological assays, transcriptome analysis, and metabolic pathways prediction. Whereas the response to pristine MP is mainly dominated by a TNF-α release, sharp-edged weathered MP induce broader adverse cellular reactions. This study stresses the importance of including more realistic test particles (e.g., weathered particles) in combination with a broad range of biological assays when evaluating the potential risk of microplastic exposure.
Further data
Item Type: |
Article in a journal
|
Refereed: |
Yes |
Keywords: |
Weathered particles; Fragments; Cytotoxicity; Biological effects; Inflammation; Genotoxicity; Transcriptomic; RNA sequencing; Microplastic; Nanoplastic
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Institutions of the University: |
Faculties Faculties > Faculty of Biology, Chemistry and Earth Sciences Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry Faculties > Faculty of Biology, Chemistry and Earth Sciences > Department of Chemistry > Chair Macromolecular Chemistry I Faculties > Faculty of Engineering Science Faculties > Faculty of Engineering Science > Chair Process Biotechnology Faculties > Faculty of Engineering Science > Chair Process Biotechnology > Chair Process Biotechnology - Univ.-Prof. Dr. Ruth Freitag Faculties > Faculty of Engineering Science > Chair Biomaterials Faculties > Faculty of Engineering Science > Chair Biomaterials > Chair Biomaterials - Univ.-Prof. Dr. Thomas Scheibel Profile Fields Profile Fields > Advanced Fields Profile Fields > Advanced Fields > Polymer and Colloid Science Profile Fields > Advanced Fields > Advanced Materials Profile Fields > Advanced Fields > Molecular Biosciences Profile Fields > Emerging Fields Profile Fields > Emerging Fields > Food and Health Sciences Research Institutions Research Institutions > Central research institutes Research Institutions > Central research institutes > Bayreuth Center for Material Science and Engineering - BayMAT Research Institutions > Collaborative Research Centers, Research Unit Research Institutions > Collaborative Research Centers, Research Unit > SFB 1357 - MIKROPLASTIK |
Result of work at the UBT: |
Yes |
DDC Subjects: |
500 Science > 570 Life sciences, biology 600 Technology, medicine, applied sciences 600 Technology, medicine, applied sciences > 600 Technology 600 Technology, medicine, applied sciences > 610 Medicine and health 600 Technology, medicine, applied sciences > 620 Engineering |
Date Deposited: |
24 Oct 2023 06:46 |
Last Modified: |
29 Nov 2023 12:06 |
URI: |
https://eref.uni-bayreuth.de/id/eprint/87371 |
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