Veröffentlichungen "Wöhrl, Birgitta M."

2025

Hendrich, Julian ; Kara, Hatice ; Schweimer, Kristian ; Jacob, Thessa ; Schneider, Maike ; Baldermann, Susanne ; Wöhrl, Birgitta M.:
Identification of glycosylated flavonoids as new physiological ligands of the hazel allergen Cor a 1 : Complex structures reveal different binding orientation and specificity of mono- and disaccharide derivatives.
In: Food Chemistry: X. Bd. 29 (2025) . - 102711.
ISSN 2590-1575
DOI: https://doi.org/10.1016/j.fochx.2025.102711

2024

Hendrich, Julian ; Reuter, Andreas ; Jacob, Thessa ; Kara, Hatice ; Amer, Sherine ; Rödel, Katharina ; Wöhrl, Birgitta M.:
Allergenicity and structural properties of new Cor a 1 isoallergens from hazel identified in different plant tissues.
In: Scientific Reports. Bd. 14 (2024) Heft 1 . - 5618.
ISSN 2045-2322
DOI: https://doi.org/10.1038/s41598-024-55856-2

2023

Hendrich, Julian ; Wangorsch, Andrea ; Rödel, Katharina ; Jacob, Thessa ; Mahler, Vera ; Wöhrl, Birgitta M.:
Allergenicity and IgE Recognition of New Dau c 1 Allergens from Carrot.
In: Molecular Nutrition & Food Research. Bd. 67 (2023) Heft 3 . - 2200421.
ISSN 1613-4133
DOI: https://doi.org/10.1002/mnfr.202200421

Adolph, Ramona S. ; Beck, Eileen ; Schweimer, Kristian ; Di Fonzo, Andrea ; Weyand, Michael ; Rösch, Paul ; Wöhrl, Birgitta M. ; Steegborn, Clemens:
Molecular Mechanism of Sirtuin 1 Inhibition by Human Immunodeficiency Virus 1 Tat Protein.
In: Life. Bd. 13 (2023) Heft 4 . - 949.
ISSN 2075-1729
DOI: https://doi.org/10.3390/life13040949

2022

Haumaier, Franziska ; Schneider-Fuchs, Anna ; Backert, Steffen ; Vieth, Michael ; Sterlacci, William ; Wöhrl, Birgitta M.:
Rapid Detection of Quinolone Resistance Mutations in gyrA of Helicobacter pylori by Real-Time PCR.
In: Pathogens. Bd. 11 (2022) Heft 1 . - 59.
ISSN 2076-0817
DOI: https://doi.org/10.3390/pathogens11010059

2021

Chruszcz, Maksymilian ; Chew, Fook Tim ; Hoffmann-Sommergruber, Karin ; Hurlburt, Barry K. ; Mueller, Geoffrey A. ; Pomés, Anna ; Rouvinen, Juha ; Villalba, Mayte ; Wöhrl, Birgitta M. ; Breiteneder, Heimo:
Allergens and their associated small molecule ligands : their dual role in sensitization.
In: Allergy. Bd. 76 (2021) Heft 8 . - S. 2367-2382.
ISSN 1398-9995
DOI: https://doi.org/10.1111/all.14861

Jacob, Thessa ; Wangorsch, Andrea ; Vogel, Lothar ; Reuter, Andreas ; Mahler, Vera ; Wöhrl, Birgitta M.:
A Novel Isoallergen Dau c 1.0401 in Carrot : Stability, Allergenicity, and Comparison with Other Isoallergens.
In: Molecular Nutrition & Food Research. Bd. 65 (2021) Heft 7 . - 2001110.
ISSN 1613-4133
DOI: https://doi.org/10.1002/mnfr.202001110

Boritzki, Vanessa ; Hübner, Harald ; Allikalt, Anni ; Gmeiner, Peter ; Wöhrl, Birgitta M.:
Optimizing the Expression of Human Dopamine Receptors in Escherichia coli.
In: International Journal of Molecular Sciences. Bd. 22 (2021) Heft 16 . - 8647.
ISSN 1422-0067
DOI: https://doi.org/10.3390/ijms22168647

Nowacka, Marzena ; Nowak, Elzbieta ; Czarnocki-Cieciura, Mariusz ; Jackiewicz, Justyna ; Skowronek, Krzysztof ; Szczepanowski, Roman H. ; Wöhrl, Birgitta M. ; Nowotny, Marcin:
Structures of substrate complexes of foamy viral protease-reverse transcriptase.
In: Journal of Virology. Bd. 95 (2021) Heft 18 . - e00848-21.
ISSN 1098-5514
DOI: https://doi.org/10.1128/JVI.00848-21

2020

Jacob, Thessa ; Vogel, Lothar ; Reuter, Andreas ; Wangorsch, Andrea ; Kring, Carolin ; Mahler, Vera ; Wöhrl, Birgitta M.:
Food Processing does not Abolish the Allergenicity of the Carrot Allergen Dau c 1 : Influence of pH, Temperature and the Food Matrix.
In: Molecular Nutrition & Food Research. Bd. 64 (2020) Heft 18 . - 2000334.
ISSN 1613-4133
DOI: https://doi.org/10.1002/mnfr.202000334

Hartl, Frederike A. ; Beck-García, Esmeralda ; Woessner, Nadine M. ; Flachsmann, Lea J. ; Velasco Cárdenas, Rubí M.-H. ; Brandl, Simon M. ; Taromi, Sanaz ; Fiala, Gina J. ; Morath, Anna ; Mishra, Pankaj ; Yousefi, O. Sascha ; Zimmermann, Julia ; Hoefflin, Nico ; Köhn, Maja ; Wöhrl, Birgitta M. ; Zeiser, Robert ; Schweimer, Kristian ; Günther, Stefan ; Schamel, Wolfgang W. ; Minguet, Susana:
Noncanonical binding of Lck to CD3ε promotes TCR signaling and CAR function.
In: Nature Immunology. Bd. 21 (2020) . - S. 902-913.
ISSN 1529-2916
DOI: https://doi.org/10.1038/s41590-020-0732-3

2019

Jacob, Thessa ; Seutter von Loetzen, Christian ; Reuter, Andreas ; Lacher, Ulrike ; Schiller, Dirk ; Schobert, Rainer ; Mahler, Vera ; Vieths, Stefan ; Rösch, Paul ; Schweimer, Kristian ; Wöhrl, Birgitta M.:
Identification of a natural ligand of the hazel allergen Cor a 1.
In: Scientific Reports. Bd. 9 (2019) . - 8714.
ISSN 2045-2322
DOI: https://doi.org/10.1038/s41598-019-44999-2

Wöhrl, Birgitta M.:
Structural and Functional Aspects of Foamy Virus Protease-Reverse Transcriptase.
In: Viruses. Bd. 11 (2019) Heft 7 . - 598.
ISSN 1999-4915
DOI: https://doi.org/10.3390/v11070598

2018

Zuber, Philipp ; Hahn, Lukas ; Reinl, Anne ; Schweimer, Kristian ; Knauer, Stefan H. ; Gottesman, Max E. ; Rösch, Paul ; Wöhrl, Birgitta M.:
Structure and nucleic acid binding properties of KOW domains 4 and 6–7 of human transcription elongation factor DSIF.
In: Scientific Reports. Bd. 8 (2018) . - 11660.
ISSN 2045-2322
DOI: https://doi.org/10.1038/s41598-018-30042-3

2017

Drögemüller, Johanna ; Schneider, Christin ; Schweimer, Kristian ; Strauß, Martin ; Wöhrl, Birgitta M. ; Rösch, Paul ; Knauer, Stefan H.:
Thermotoga maritima NusG : domain interaction mediates autoinhibition and thermostability.
In: Nucleic Acids Research. Bd. 45 (2017) Heft 1 . - S. 446-460.
ISSN 1362-4962
DOI: https://doi.org/10.1093/nar/gkw1111

2016

Schneider, Anna ; Corona, Angela ; Spöring, Imke ; Jordan, Mareike ; Buchholz, Bernd ; Maccioni, Elias ; di Santo, Roberto ; Bodem, Jochen ; Tramontano, Enzo ; Wöhrl, Birgitta M.:
Biochemical characterization of a multi-drug resistant HIV-1 subtype AG reverse transcriptase : antagonism of AZT discrimination and excision pathways and sensitivity to RNase H inhibitors.
In: Nucleic Acids Research. Bd. 44 (2016) Heft 5 . - S. 2310-2322.
ISSN 1362-4962
DOI: https://doi.org/10.1093/nar/gkw060

Strauß, Martin ; Schweimer, Kristian ; Burmann, Björn M. ; Richter, Anne ; Güttler, Stephanie ; Wöhrl, Birgitta M. ; Rösch, Paul:
The two domains of Mycobacterium tuberculosis NusG protein are dynamically independent.
In: Journal of Biomolecular Structure & Dynamics. Bd. 34 (2016) Heft 2 . - S. 352-361.
ISSN 1538-0254
DOI: https://doi.org/10.1080/07391102.2015.1031700

2015

Schneider, Anna ; Schweimer, Kristian ; Rösch, Paul ; Wöhrl, Birgitta M.:
AZT resistance alters enzymatic properties and creates an ATP-binding site in SFVmac reverse transcriptase.
In: Retrovirology. Bd. 12 (2015) . - 21.
ISSN 1742-4690
DOI: https://doi.org/10.1186/s12977-015-0147-7

Drögemüller, Johanna ; Strauß, Martin ; Schweimer, Kristian ; Wöhrl, Birgitta M. ; Knauer, Stefan H. ; Rösch, Paul:
Exploring RNA polymerase regulation by NMR spectroscopy.
In: Scientific Reports. Bd. 5 (2015) . - 10825.
ISSN 2045-2322
DOI: https://doi.org/10.1038/srep10825

2014

Corona, Angela ; Schneider, Anna ; Schweimer, Kristian ; Rösch, Paul ; Wöhrl, Birgitta M. ; Tramontano, Enzo:
Inhibition of foamy virus reverse transcriptase by human immunodeficiency virus type 1 ribonuclease H inhibitors.
In: Antimicrobial Agents and Chemotherapy. Bd. 58 (2014) Heft 7 . - S. 4086-4093.
ISSN 1098-6596
DOI: https://doi.org/10.1128/AAC.00056-14

Weiglmeier, Philipp Richard ; Berkner, Hanna ; Seebahn, Angela ; Vogel, Nico ; Schreiber, Rainer ; Wöhrl, Birgitta M. ; Schwarzinger, Stephan ; Rösch, Paul:
Prosequence switching : An effective strategy to produce biologically active E. coli heat-stable enterotoxin STh.
In: Journal of Biomolecular Structure & Dynamics. Bd. 32 (2014) Heft 10 . - S. 1-9.
ISSN 1538-0254
DOI: https://doi.org/10.1080/07391102.2013.825758

Schneider, Anna ; Peter, Daniel ; Schmitt, Jessica ; Leo, Berit ; Richter, Franziska ; Rösch, Paul ; Wöhrl, Birgitta M. ; Hartl, Maximilian J.:
Structural requirements for enzymatic activities of foamy virus protease-reverse transcriptase.
In: Proteins: Structure, Function, and Bioinformatics. Bd. 82 (2014) Heft 3 . - S. 375-385.
ISSN 1097-0134
DOI: https://doi.org/10.1002/prot.24394

2013

Drögemüller, Johanna ; Stegmann, Christian M. ; Mandal, Angshuman ; Steiner, Thomas ; Burmann, Björn M. ; Gottesman, Max E. ; Wöhrl, Birgitta M. ; Rösch, Paul ; Wahl, Markus C. ; Schweimer, Kristian:
An Autoinhibited State in the Structure of Thermotoga maritima NusG.
In: Structure. Bd. 21 (2013) Heft 3 . - S. 365-375.
ISSN 0969-2126
DOI: https://doi.org/10.1016/j.str.2012.12.015

Spannaus, Ralf ; Schneider, Anna ; Hartl, Maximilian J. ; Wöhrl, Birgitta M. ; Bodem, Jochen:
Foamy Virus Gag p71-p68 Cleavage Is Required for Template Switch of the Reverse Transcriptase.
In: Journal of Virology. Bd. 87 (2013) Heft 13 . - S. 7774-7776.
ISSN 1098-5514
DOI: https://doi.org/10.1128/JVI.00833-13

Schrom, Eva-Maria ; Moschall, Rebecca ; Hartl, Maximilian J. ; Weitner, Helena ; Fecher, David ; Langemeier, Jörg ; Bohne, Jens ; Wöhrl, Birgitta M. ; Bodem, Jochen:
U1snRNP-mediated suppression of polyadenylation in conjunction with the RNA structure controls poly (A) site selection in foamy viruses.
In: Retrovirology. Bd. 10 (2013) . - 55.
ISSN 1742-4690
DOI: https://doi.org/10.1186/1742-4690-10-55

2012

Hartl, Maximilian J. ; Burmann, Björn M. ; Prasch, Stefan J. ; Schwarzinger, Clemens ; Schweimer, Kristian ; Wöhrl, Birgitta M. ; Rösch, Paul ; Schwarzinger, Stephan:
Fast Mapping of Biomolecular Interfaces by Random Spin Labeling (RSL).
In: Journal of Biomolecular Structure & Dynamics. Bd. 29 (2012) Heft 4 . - S. 793-798.
ISSN 1538-0254

Leo, Berit ; Hartl, Maximilian J. ; Schweimer, Kristian ; Mayr, Florian ; Wöhrl, Birgitta M.:
Insights into the structure and activity of prototype foamy virus RNase H.
In: Retrovirology. Bd. 9 (2012) . - 14.
ISSN 1742-4690
DOI: https://doi.org/10.1186/1742-4690-9-14

Spannaus, Ralf ; Hartl, Maximilian J. ; Wöhrl, Birgitta M. ; Rethwilm, Axel ; Bodem, Jochen:
The prototype foamy virus protease is active independently of the integrase domain.
In: Retrovirology. Bd. 9 (2012) . - 41.
ISSN 1742-4690
DOI: https://doi.org/10.1186/1742-4690-9-41

Leo, Berit ; Schweimer, Kristian ; Rösch, Paul ; Hartl, Maximilian J. ; Wöhrl, Birgitta M.:
The solution structure of the prototype foamy virus RNase H domain indicates an important role of the basic loop in substrate binding.
In: Retrovirology. Bd. 9 (2012) . - 73.
ISSN 1742-4690
DOI: https://doi.org/10.1186/1742-4690-9-73

2011

Hartl, Maximilian J. ; Bodem, Jochen ; Jochheim, Fabian ; Rethwilm, Axel ; Rösch, Paul ; Wöhrl, Birgitta M.:
Regulation of foamy virus protease activity by viral RNA.
In: Journal of Virology. Bd. 85 (2011) Heft 9 . - S. 4462-4469.
ISSN 1098-5514
DOI: https://doi.org/10.1128/JVI.02211-10

2010

Hartl, Maximilian J. ; Mayr, Florian ; Rethwilm, Axel ; Wöhrl, Birgitta M.:
Biophysical and enzymatic properties of the simian and prototype foamy virus reverse transcriptases.
In: Retrovirology. Bd. 7 (2010) . - 5.
ISSN 1742-4690
DOI: https://doi.org/10.1186/1742-4690-7-5

Wenzel, Sabine ; Martins, Berta M. ; Rösch, Paul ; Wöhrl, Birgitta M.:
Crystal structure of the human transcription elongation factor DSIF hSpt4 subunit in complex with the hSpt5 dimerization interface.
In: Biochemical Journal. Bd. 425 (2010) Heft 2 . - S. 373-380.
ISSN 1470-8728
DOI: https://doi.org/10.1042/BJ20091422

Hartl, Maximilian J. ; Schweimer, Kristian ; Reger, Martin ; Schwarzinger, Stephan ; Bodem, Jochen ; Rösch, Paul ; Wöhrl, Birgitta M.:
Formation of transient dimers by a retroviral protease.
In: Biochemical Journal. Bd. 427 (2010) Heft 2 . - S. 197-203.
ISSN 1470-8728
DOI: https://doi.org/10.1042/BJ20091451

2009

Prasch, Stefan J. ; Jurk, Marcel ; Washburn, Robert S. ; Gottesman, Max E. ; Wöhrl, Birgitta M. ; Rösch, Paul:
RNA-binding specificity of E. coli NusA.
In: Nucleic Acids Research. Bd. 37 (2009) Heft 14 . - S. 4736-4742.
ISSN 1362-4962
DOI: https://doi.org/10.1093/nar/gkp452

2008

Hartl, Maximilian J. ; Kretzschmar, Benedikt ; Frohn, Anne ; Nowrouzi, Ali ; Rethwilm, Axel ; Wöhrl, Birgitta M.:
AZT resistance of simian foamy virus reserve transcriptase is based on the excision of AZTMP in the presence of ATP.
In: Nucleic Acids Research. Bd. 36 (2008) Heft 3 . - S. 1009-1016.
ISSN 1362-4962
DOI: https://doi.org/10.1093/nar/gkm1087

Kretzschmar, Benedikt ; Nowrouzi, Ali ; Hartl, Maximilian J. ; Gärtner, Kathleen ; Wiktorowicz, Tatiana ; Herchenröder, Ottmar ; Kanzler, Sylvia ; Rudolph, Wolfram ; Mergia, Ayalew ; Wöhrl, Birgitta M. ; Rethwilm, Axel:
AZT-resistant foamy virus.
In: Virology. Bd. 370 (2008) Heft 1 . - S. 151-157.
ISSN 0042-6822
DOI: https://doi.org/10.1016/j.virol.2007.08.025

Rao Jampani, Nageswara ; Schweimer, Kristian ; Wenzel, Sabine ; Wöhrl, Birgitta M. ; Rösch, Paul:
NELF-E RRM undergoes major structural changes in flexible protein regions on target RNA binding.
In: Biochemistry. Bd. 47 (2008) Heft 12 . - S. 3756-3761.
ISSN 1520-4995
DOI: https://doi.org/10.1021/bi702429m

Wenzel, Sabine ; Schweimer, Kristian ; Rösch, Paul ; Wöhrl, Birgitta M.:
The small hSpt4 subunit of the human transcription elongation factor DSIF is a Zn-finger protein with α/β type topology.
In: Biochemical and Biophysical Research Communications. Bd. 370 (2008) Heft 3 . - S. 414-418.
ISSN 1090-2104
DOI: https://doi.org/10.1016/j.bbrc.2008.03.080

Hartl, Maximilian J. ; Wöhrl, Birgitta M. ; Rösch, Paul ; Schweimer, Kristian:
The Solution Structure of the Simian Foamy Virus Protease Reveals a Monomeric Protein.
In: Journal of Molecular Biology. Bd. 381 (2008) Heft 1 . - S. 141-149.
ISSN 0022-2836
DOI: https://doi.org/10.1016/j.jmb.2008.05.064

2007

Berkner, Hanna ; Engelhorn, Julia ; Liscombe, David K. ; Schweimer, Kristian ; Wöhrl, Birgitta M. ; Facchini, Peter J. ; Rösch, Paul ; Matecko, Irena:
High-yield expression and purification of isotopically labeled norcoclaurine synthase, a Bet v 1-homologous enzyme, from Thalictrum flavum for NMR studies.
In: Protein Expression and Purification. Bd. 56 (2007) Heft 2 . - S. 197-204.
ISSN 1046-5928
DOI: https://doi.org/10.1016/j.pep.2007.07.010

Hartl, Maximilian J. ; Wöhrl, Birgitta M. ; Schweimer, Kristian:
Sequence-specific ¹H, ¹³C and ¹⁵N resonance assignments and secondary structure of a truncated protease from Simian Foamy Virus.
In: Biomolecular NMR Assignments. Bd. 1 (2007) . - S. 175-177.
ISSN 1874-270X
DOI: https://doi.org/10.1007/s12104-007-9048-6

2006

Prasch, Stefan J. ; Schwarz, Sabine ; Eisenmann, Anke ; Wöhrl, Birgitta M. ; Schweimer, Kristian ; Rösch, Paul:
Interaction of the Intrinsically Unstructured Phage λ N Protein with Escherichia coli NusA.
In: Biochemistry. Bd. 45 (2006) Heft 14 . - S. 4542-4549.
ISSN 1520-4995
DOI: https://doi.org/10.1021/bi0523411

Rao Jampani, Nageswara ; Neumann, Liane ; Wenzel, Sabine ; Schweimer, Kristian ; Rösch, Paul ; Wöhrl, Birgitta M.:
Structural studies on the RNA-recognition motif of NELF E, a cellular negative transcription elongation factor involved in the regulation of HIV transcription.
In: Biochemical Journal. Bd. 400 (2006) Heft 3 . - S. 449-456.
ISSN 1470-8728
DOI: https://doi.org/10.1042/BJ20060421

2005

Wöhrl, Birgitta M. ; Loubière, Laurence ; Brundiers, Ralf ; Goody, Roger S. ; Klatzmann, David ; Konrad, Manfred:
Expressing engineered thymidylate kinase variants in human cells to improve AZT phosphorylation and human immunodeficiency virus inhibition.
In: Journal of General Virology. Bd. 86 (2005) Heft 3 . - S. 757-764.
ISSN 1465-2099
DOI: https://doi.org/10.1099/vir.0.80529-0

2004

Faltz, Heike ; Bender, Christoph ; Wöhrl, Birgitta M. ; Vogel‐Bachmayr, Karin ; Hübscher, Ullrich ; Ramadan, Kristijan ; Liebscher, Jürgen:
Double Cyclization of Bis(α‐hetarylmethyl)amino Esters to Optically Active Bridged N‐Heterocycles of HIV‐Inhibiting Activitv.
In: European Journal of Organic Chemistry. (2004) Heft 16 . - S. 3484-3496.
ISSN 1099-0690
DOI: https://doi.org/10.1002/ejoc.200400136

2003

Wöhrl, Birgitta M.:
Antiterminationskomplexe als Ziel neuer Therapeutika.
In: Retrovirus-Bulletin. (2003) Heft 2 . - S. 4-6.

Rothwell, P. J. ; Berger, S. ; Kensch, O. ; Felekyan, S. ; Antonik, M. ; Wöhrl, Birgitta M. ; Restle, Tobias ; Goody, Roger S. ; Seidel, C. A. M.:
Multiparameter single-molecule fluorescence spectroscopy reveals heterogeneity of HIV-1 reverse transcriptase:primer/template complexes.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 100 (2003) Heft 4 . - S. 1655-1660.
ISSN 1091-6490
DOI: https://doi.org/10.1073/pnas.0434003100

Roda, Ricardo H. ; Balakrishnan, Mini ; Hanson, Mark N. ; Wöhrl, Birgitta M. ; Le Grice, Stuart F. J. ; Roques, Bernhard P. ; Gorelick, Robert J. ; Bambara, Robert A.:
Role of the reverse transcriptase, nucleocapsid protein and template structure in the two-step transfer mechanism in retroviral recombination.
In: The Journal of Biological Chemistry. Bd. 278 (2003) Heft 34 . - S. 31536-31546.
ISSN 1083-351X
DOI: https://doi.org/10.1074/jbc.M304608200

2002

Hollinderbäumer, Britta ; Wöhrl, Birgitta M.:
Resistenzmechanismen von HIV.
In: Bioforum. Bd. 25 (2002) . - S. 406-408.
ISSN 0940-0079

Werner, Susanne ; Hindmarsh, Patrick ; Napirei, Markus ; Vogel-Bachmayr, Karin ; Wöhrl, Birgitta M.:
Subcellular localization and integration activities of Rous Sarcoma Virus reverse transcriptase.
In: Journal of Virology. Bd. 76 (2002) Heft 12 . - S. 6205-6212.
ISSN 1098-5514
DOI: https://doi.org/10.1128/JVI.76.12.6205-6212.2002

2001

Werner, Susanne ; Vogel-Bachmayr, Karin ; Hollinderbäumer, Britta ; Wöhrl, Birgitta M.:
Requirements for Minus-Strand Transfer Catalyzed by Rous Sarcoma Virus Reverse Transcriptase.
In: Journal of Virology. Bd. 75 (2001) Heft 21 . - S. 10132-10138.
ISSN 1098-5514
DOI: https://doi.org/10.1128/JVI.75.21.10132-10138.2001

2000

Werner, Susanne ; Wöhrl, Birgitta M.:
Asymmetric Subunit Organization of Heterodimeric Rous Sarcoma Virus Reverse Transcriptase αβ : Localization of the Polymerase and RNase H Active Sites in the α Subunit.
In: Journal of Virology. Bd. 74 (2000) Heft 7 . - S. 3245-3252.
ISSN 1098-5514
DOI: https://doi.org/10.1128/jvi.74.7.3245-3252.2000

Werner, Susanne ; Wöhrl, Birgitta M.:
Homodimeric reverse transcriptases from Rous Sarcoma Virus mutated within the polymerase or RNase H active site of one subunit are active.
In: European Journal of Biochemistry. Bd. 267 (2000) Heft 15 . - S. 4740-4744.
ISSN 1432-1033
DOI: https://doi.org/10.1046/j.1432-1327.2000.01530.x

Kensch, Oliver ; Restle, Tobias ; Wöhrl, Birgitta M. ; Goody, Roger S. ; Steinhoff, Heinz-Jürgen:
Temperature-dependent equilibrium between the open and closed conformation of the p66 subunit of the HIV-1 reverse transcriptase revealed by site-directed spin labelling.
In: Journal of Molecular Biology. Bd. 301 (2000) Heft 4 . - S. 1029-1039.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.2000.3998

1999

Wöhrl, Birgitta M. ; Krebs, Ruth ; Goody, Roger S. ; Restle, Tobias:
Refined model for primer/template binding by HIV-1 reverse transcriptase : pre-steady-state kinetic analyses of primer/template binding and nucleotide incorporation events distinguish between different binding modes depending on the nature of the nucleic acid substrate.
In: Journal of Molecular Biology. Bd. 292 (1999) Heft 2 . - S. 333-344.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.1999.3057

Werner, Susanne ; Wöhrl, Birgitta M.:
Soluble Rous Sarcoma Virus reverse transcriptases α, αβ, and β purified from insect cells are processive DNA polymerases that lack an RNase H 3' → 5' directed processing activity.
In: The Journal of Biological Chemistry. Bd. 274 (1999) Heft 37 . - S. 26329-26336.
ISSN 1083-351X
DOI: https://doi.org/10.1074/jbc.274.37.26329

1998

Souquet, Manfred ; Restle, Tobias ; Krebs, Ruth ; Le Grice, Stuart F.J. ; Goody, Roger S. ; Wöhrl, Birgitta M.:
Analysis of the polymerization kinetics of homodimeric EIAV p51/51 reverse transcriptase implies the formation of a polymerase active site identical to heterodimeric EIAV p66/51 reverse transcriptase.
In: Biochemistry. Bd. 37 (1998) Heft 35 . - S. 12144-12152.
ISSN 1520-4995
DOI: https://doi.org/10.1021/bi9731596

Krebs, Ruth ; Wöhrl, Birgitta M. ; Cellai, Luciano ; Goody, Roger S. ; Restle, Tobias:
Pre-steady-state kinetic characterization of RNA-primed initiation of transcription by HIV-1 reverse transcriptase and analysis of the transition to a processive DNA-primed polymerization mode.
In: Biochemistry. Bd. 37 (1998) Heft 38 . - S. 13349-13358.
ISSN 1520-4995
DOI: https://doi.org/10.1021/bi981102t

1997

Wöhrl, Birgitta M. ; Krebs, Ruth ; Thrall, Sara H. ; Le Grice, Stuart F.J. ; Scheidig, Axel J. ; Goody, Roger S.:
Kinetic analysis of four HIV-1 reverse transcriptase enzymes mutated in the primer grip grip region of p66 : implications for DNA synthesis and dimerization.
In: The Journal of Biological Chemistry. Bd. 272 (1997) . - S. 17581-17587.
ISSN 1083-351X
DOI: https://doi.org/10.1074/jbc.272.28.17581

Krebs, Ruth ; Immendörfer, Ulrike ; Thrall, Sara H. ; Wöhrl, Birgitta M. ; Goody, Roger S.:
Single-Step Kinetics of HIV-1 Reverse Transcriptase Mutants Responsible for Virus Resistance to Nucleoside Inhibitors Zidovudine and 3-TC.
In: Biochemistry. Bd. 36 (1997) Heft 33 . - S. 10292-10300.
ISSN 1520-4995
DOI: https://doi.org/10.1021/bi970512z

1996

Thrall, Sara H. ; Reinstein, Jochen ; Wöhrl, Birgitta M. ; Goody, Roger S.:
Evaluation of Human immunodeficiency virus type 1 reverse transcriptase primer tRNA binding by fluorescence spectroscopy :  specificity and comparison to primer/template binding.
In: Biochemistry. Bd. 35 (1996) Heft 14 . - S. 4609-4618.
ISSN 1520-4995
DOI: https://doi.org/10.1021/bi9526387

Arts, Eric J. ; Stetor, S. R. ; Li, X. ; Rausch, J. W. ; Howard, K. J. ; Ehresmann, Bernard ; North, T. W. ; Wöhrl, Birgitta M. ; Goody, Roger S. ; Wainberg, M. A. ; Grice, S. F. J.:
Initiation of (-) strand DNA synthesis from tRNA(3Lys) on lentiviral RNAs : Implications of specific HIV-1 RNA-tRNA(3Lys) interactions inhibiting primer utilization by retroviral reverse transcriptases.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 93 (1996) Heft 19 . - S. 10063-10068.
ISSN 1091-6490
DOI: https://doi.org/10.1073/pnas.93.19.10063

Rausch, Jason W. ; Arts, Eric J. ; Wöhrl, Birgitta M. ; Le Grice, Stuart F.J.:
Involvement of C-terminal structural elements of Equine Infectious Anemia Virus reverse transcriptase in DNA polymerase and ribonuclease H activities.
In: Journal of Molecular Biology. Bd. 257 (1996) Heft 3 . - S. 500-511.
ISSN 0022-2836
DOI: https://doi.org/10.1006/jmbi.1996.0181

1995

Wöhrl, Birgitta M. ; Tantillo, Chris ; Arnold, Edward ; Le Grice, Stuart F.J.:
An Expanded Model of Replicating Human Immunodeficiency Virus Reverse Transcriptase.
In: Biochemistry. Bd. 34 (1995) Heft 16 . - S. 5343-5350.
ISSN 1520-4995
DOI: https://doi.org/10.1021/bi00016a005

Wöhrl, Birgitta M. ; Georgiadis, M. M. ; Telesnitsky, A. ; Hendrickson, W. A. ; Le Grice, Stuart F. J.:
Footprint analysis of replicating murine leukemia virus reverse transcriptase.
In: Science. Bd. 267 (1995) Heft 5194 . - S. 96-99.
ISSN 1095-9203
DOI: https://doi.org/10.1126/science.7528942

Wehmeier, Udo F. ; Wöhrl, Birgitta M. ; Lengeler, Joseph W.:
Molecular analysis of the phosphoenolpyruvate-dependent L-sorbose : phosphotransferase system from Klebsiella pneumoniae and of its multidomain structure.
In: Molecular and General Genetics. Bd. 246 (1995) Heft 5 . - S. 610-618.
ISSN 0026-8925
DOI: https://doi.org/10.1007/BF00298968

1994

Wöhrl, Birgitta M. ; Howard, Kathryn J. ; Jacques, Pamela S. ; Le Grice, Stuart F.J.:
Alternative modes of polymerization distinguish the subunits of equine infectious anemia virus reverse transcriptase.
In: The Journal of Biological Chemistry. Bd. 269 (1994) Heft 11 . - S. 8541-8548.
ISSN 1083-351X

Jacques, Pamela S. ; Wöhrl, Birgitta M. ; Howard, Kathryn J. ; Le Grice, Stuart F.J.:
Modulation of HIV-1 reverse transcriptase function in "selectively deleted" p66/p51 heterodimers.
In: The Journal of Biological Chemistry. Bd. 269 (1994) Heft 2 . - S. 1388-1393.
ISSN 1083-351X

Jacques, Pamela S. ; Wöhrl, Birgitta M. ; Ottmann, Michele ; Darlix, Jean-Luc ; Le Grice, Stuart F.J.:
Mutating the "primer grip" of p66 HIV-1 reverse transcriptase implicates Tryptophan-229 in template-primer utilization.
In: The Journal of Biological Chemistry. Bd. 269 (1994) Heft 42 . - S. 26472-26478.
ISSN 1083-351X

1993

Volkmann, Silke ; Wöhrl, Birgitta M. ; Tisdale, Margaret ; Moelling, Karin:
Enzymatic analysis of two HIV-1 reverse transcriptase mutants with mutations in carboxyl-terminal amino acid residues conserved among retroviral ribonucleases H.
In: The Journal of Biological Chemistry. Bd. 268 (1993) Heft 4 . - S. 2674-2683.
ISSN 1083-351X

Wöhrl, Birgitta M. ; Ehresmann, Bernard ; Keith, Gerhard ; Le Grice, Stuart F.J.:
Nuclease footprinting of human immunodeficiency virus reverse transcriptase/tRNA(Lys-3) complexes.
In: The Journal of Biological Chemistry. Bd. 268 (1993) Heft 18 . - S. 13617-13624.
ISSN 1083-351X

1992

Richter-Cook, Nancy J. ; Howard, Kathryn J. ; Cirino, Nick M. ; Wöhrl, Birgitta M. ; Le Grice, Stuart F.J.:
Interaction of tRNA(Lys-3) with multiple forms of human immunodeficiency virus reverse transcriptase.
In: The Journal of Biological Chemistry. Bd. 267 (1992) Heft 22 . - S. 15952-15957.
ISSN 1083-351X

Le Grice, Stuart F. J. ; Richter-Cook, Nancy J. ; Cirino, Nick M. ; Howard, K. J. ; Wöhrl, Birgitta M. ; Barat, C. ; Naas, T. ; Schatz, O. ; Darlix, J.-L.:
Role of HIV reverse transcriptase subunits in enzyme structure and function.
In: Lilley, David M.J. ; Heumann, Hermann ; Suck, Dietrich (Hrsg.): Structural tools for the analysis of protein-nucleic acid complexes editor. - Basel : Birkhäuser Verlag , 1992 . - S. 369-390
ISBN 0-8176-2776-8

1991

Wöhrl, Birgitta M. ; Volkmann, Silke ; Moelling, Karin:
Mutations of a conserved residue within HIV-1 ribonuclease H affect its exo- and endonuclease activities.
In: Journal of Molecular Biology. Bd. 220 (1991) Heft 3 . - S. 801-818.
ISSN 0022-2836
DOI: https://doi.org/10.1016/0022-2836(91)90119-Q

Moelling, Karin ; Wöhrl, Birgitta M. ; Tisdale, Margaret ; Volkmann, Silke ; Goren, I.:
RNase H as potential target for antiviral drugs.
In: Wissenschaftliche Zeitschrift der Humboldt-Universität zu Berlin : Reihe Medizin. (1991) Heft 4 . - S. 15-19.
ISSN 0863-064X

1990

Wöhrl, Birgitta M. ; Lengeler, Joseph W.:
Cloning and physical mapping of the sor genes for L‐sorbose transport and metabolism from Klebsiella pneumoniae.
In: Molecular Microbiology. Bd. 4 (1990) Heft 9 . - S. 1557-1565.
ISSN 1365-2958
DOI: https://doi.org/10.1111/j.1365-2958.1990.tb02067.x

Wöhrl, Birgitta M. ; Sprenger, Georg A. ; Lengeler, Joseph W.:
Construction of a new catabolic pathway for D-fructose in Escherichia coli K12 using an L-sorbose-specific enzyme from Klebsiella pneumoniae.
In: Archives of Microbiology. Bd. 154 (1990) Heft 2 . - S. 162-167.
ISSN 1432-072X
DOI: https://doi.org/10.1007/BF00423327

Wöhrl, Birgitta M. ; Moelling, Karin:
Interaction of HIV-1 ribonuclease H with polypurine tract containing RNA-DNA hybrids.
In: Biochemistry. Bd. 29 (1990) Heft 44 . - S. 10141-10147.
ISSN 1520-4995
DOI: https://doi.org/10.1021/bi00496a001

Wöhrl, Birgitta M. ; Wehmeier, Udo F. ; Lengeler, Joseph W.:
Positive and negative regulation of expression of the L-sorbose (sor) operon by SorC in Klebsiella pneumoniae.
In: Molecular and General Genetics. Bd. 224 (1990) Heft 2 . - S. 193-200.
ISSN 0026-8925
DOI: https://doi.org/10.1007/BF00271552

Lengeler, Joseph W. ; Titgemeyer, F. ; Vogler, A. P. ; Wöhrl, Birgitta M.:
Structure and homologies of carbohydrate : phosphotransferase system (PTS) proteins.
In: Philosophical Transactions of the Royal Society B: Biological Sciences. Bd. 326 (1990) Heft 1236 . - S. 489-504.
ISSN 0962-8436
DOI: https://doi.org/10.1098/rstb.1990.0027