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Lehrstuhl Biochemie III - Proteindesign - Univ.-Prof. Dr. Birte Höcker

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Universität Bayreuth (64246)
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  - Fakultät für Biologie, Chemie und Geowissenschaften (18413)
    - Fachgruppe Chemie (5687)
      - Lehrstuhl Biochemie III - Proteindesign (94)
        Lehrstuhl Biochemie III - Proteindesign - Univ.-Prof. Dr. Birte Höcker (93)

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Anzahl der Einträge auf dieser Ebene: 93.

Artikel in einer Zeitschrift

Ai, Hui-wang ; Arnold, Frances H. ; Barrick, Doug ; Bayley, Hagan ; Brownless, Alfie-Louise R. ; Campbell, Robert E. ; Castells-Graells, Roger ; Chaiyen, Pimchai ; Chica, Roberto A. ; Chisholm, Lauren O. ; Christ, Daniel ; Chu, Guo-Chao ; Chungyoun, Michael ; Eijsink, Vincent G. H. ; Elowitz, Michael B. ; Fansher, Douglas J. ; Fasan, Rudi ; Foley, Gabriel ; Frei, Michelle S. ; Gagsteiger, Andreas ; Gao, Ruiyan ; Gillam, Elizabeth M. J. ; Gray, Jeffrey J. ; Guerra, Luis F. ; Höcker, Birte ; Jin, Zhiyang ; Kamerlin, Shina Caroline Lynn ; Koga, Nobuyasu ; Kontermann, Roland E. ; Kuhlman, Brian ; Langlois, Olivia A. ; Li, Dongyang ; Lins, Roberto D. ; Liu, Chang C. ; Liu, Lei ; López Barreiro, Diego ; Lu, Peilong ; Mehta, Sohum ; Miyazaki, Ikumi ; Müller, Manuel M. ; Muyldermans, Serge ; Nemoto, Naoto ; Nivala, Jeff ; Nuñez, James K. ; Ornelas, Izaiah J. ; Pelletier, Joelle N. ; Plückthun, Andreas ; Porth, Owen T. ; Prakinee, Kridsadakorn ; Qing, Yujia ; Reisenbauer, Julia C. ; Schmidt, Sandy ; Seifert, Oliver ; Shapiro, Mikhail G. ; Sharma, Rachna ; Singh, Nilmani ; Smith, Benjamin J. ; Spangler, Jamie B. ; Tatsumi-Koga, Rie ; Terai, Takuya ; Terholsen, Henrik ; Tolhurst, Mattias ; Tripp, Katherine W. ; Trossmann, Vanessa T. ; Tucker, Chandra L. ; Turak, Onur ; Van Deventer, James A. ; Várnai, Anikó ; Viana, Isabelle F. T. ; Weeks, Amy M. ; Wittrup, K. Dane ; Wong, Kingsley L.-J. ; Xi, Chenggang ; Yeates, Todd O. ; Yeh, Andy Hsien-Wei ; Zhang, Jin ; Zhang, Tiger S. ; Zhao, Huimin ; Zheng, Fang ; Zhu, Jingyi ; Zinn, Sacha:
Protein engineering : Status report.
In: Protein Engineering, Design & Selection. (17 Juli 2026) . - gzag020.
DOI: https://doi.org/10.1093/protein/gzag020

Nilsson, Patrik ; Robertson, Neil O. ; Gustafsson, Nils ; Davies, Roberta B. ; Liew, Chu Wai ; Lyons, Aaron ; Eichhorn, Ralf ; Niman, Cassandra S. ; Blab, Gerhard A. ; Bromley, Elizabeth H. C. ; Whitten, Andrew E. ; Duff, Anthony P. ; Unksov, Ivan N. ; Beech, Jason P. ; Jönsson, Peter ; Böcking, Till ; Höcker, Birte ; Woolfson, Derek N. ; Forde, Nancy R. ; Linke, Heiner ; Curmi, Paul M. G.:
Clocked stepping of an artificial protein walker along a DNA track.
In: Nature Nanotechnology. (2026) .
DOI: https://doi.org/10.1038/s41565-026-02211-3

Beck, Julian ; Smith, Benjamin J. ; Kriegel, Mark ; Zarifi, Niayesh ; Freund, Emily ; Harsha, Ahana G. ; Hartmann, Jan ; Chica, Roberto A. ; Höcker, Birte:
Customizing the structure of minimal TIM barrels to craft efficient de novo enzymes.
In: Nature Chemical Biology. (2026) .
DOI: https://doi.org/10.1038/s41589-026-02250-w

Müller, Martin ; Sudarsan, Neeraja ; Urbach, Birgit ; Gagsteiger, Andreas ; Turak, Onur ; Fery, Andreas ; Höcker, Birte:
Enzymatic Degradation of Thin Polyester Films Studied by In-situ ATR-FTIR Spectroscopy.
In: Journal of Polymers and the Environment. Bd. 34 (2026) . - 193.
DOI: https://doi.org/10.1007/s10924-026-03908-1

Pongratz, Annalena ; Gagsteiger, Andreas ; Höcker, Birte ; Ruckdäschel, Holger:
The Key to Enzymatic Degradation of Polybutylene Terephthalate (PBT): Influence of Semicrystalline Properties on Degradation.
In: ChemSusChem. Bd. 18 (2026) Heft 24 . - e202501775.
DOI: https://doi.org/10.1002/cssc.202501775

Scherer, Marc ; Kriegel, Mark ; Höcker, Birte ; Fleishman, Sarel J.:
Optimizing stability in dynamic small-molecule binding proteins.
In: Journal of the American Chemical Society. Bd. 148 (2026) Heft 1 . - S. 1911-1918.
DOI: https://doi.org/10.1021/jacs.5c19571

Höcker, Birte ; Koch, Ina ; Hennig, Janosch:
The 76th Mosbacher Colloquium: AI-driven (r)evolution in structural biology and protein design.
In: Biological Chemistry. (30 September 2025) .
DOI: https://doi.org/10.1515/hsz-2025-0184

Upadhyay, Ashank ; Turak, Onur ; Fulajtar, Emilia ; Greve, Christopher ; Herzig, Eva M. ; Höcker, Birte ; Agarwal, Seema:
Degradation Behavior of Aliphatic–Aromatic Polyesters : from Microplastic-free Composting to Enzyme-Driven Recycling Possibility.
In: ACS Applied Polymer Materials. Bd. 7 (2025) Heft 7 . - S. 4596-4608.
DOI: https://doi.org/10.1021/acsapm.5c00296

Ayyildiz, Merve ; Noske, Jakob ; Gisdon, Florian J. ; Kynast, Josef ; Höcker, Birte:
Evaluation of Physics-Based Protein Design Methods for Predicting Single Residue Effects on Peptide Binding Specificities.
In: Journal of Computational Chemistry. Bd. 46 (2025) Heft 17 . - e70160.
DOI: https://doi.org/10.1002/jcc.70160

Turak, Onur ; Gagsteiger, Andreas ; Upadhyay, Ashank ; Kriegel, Mark ; Salein, Peter ; Böhnke-Brandt, Stefanie ; Agarwal, Seema ; Borchert, Erik ; Höcker, Birte:
A third type of PETase from the marine Halopseudomonas lineage.
In: Protein Science. Bd. 34 (2025) Heft 10 . - e70305.
DOI: https://doi.org/10.1002/pro.70305

Rydzek, Simon ; Guth, Florian ; Friedrich, Steffen ; Noske, Jakob ; Höcker, Birte ; Hahn, Frank:
Chemoenzymatic Synthesis of Plant‐Derived Kavalactone Natural Products by Dynamic Resolution Using a Biosynthetic O‐Methyltransferase Tailoring Enzyme.
In: ChemCatChem. Bd. 16 (2024) Heft 23 . - e202400883.
DOI: https://doi.org/10.1002/cctc.202400883

Beck, Julian ; Shanmugaratnam, Sooruban ; Höcker, Birte:
Diversifying de novo TIM barrels by hallucination.
In: Protein Science. Bd. 33 (2024) Heft 6 . - e5001.
DOI: https://doi.org/10.1002/pro.5001

Toledo-Patiño, Saacnicteh ; Goetz, Sara Kathrin ; Shanmugaratnam, Sooruban ; Höcker, Birte ; Farías‐Rico, José Arcadio:
Molecular handcraft of a well‐folded protein chimera.
In: FEBS Letters. Bd. 598 (2024) Heft 11 . - S. 1375-1386.
DOI: https://doi.org/10.1002/1873-3468.14856

Koch, Johanna-Sophie ; Romero-Romero, Sergio ; Höcker, Birte:
Stepwise introduction of stabilizing mutations reveals nonlinear additive effects in de novo TIM barrels.
In: Protein Science. Bd. 33 (2024) Heft 3 . - e4926.
DOI: https://doi.org/10.1002/pro.4926

Noske, Jakob ; Kynast, Josef ; Lemm, Dominik ; Schmidt, Steffen ; Höcker, Birte:
PocketOptimizer 2.0 : A modular framework for computer‐aided ligand‐binding design.
In: Protein Science. Bd. 32 (2023) Heft 1 . - e4516.
DOI: https://doi.org/10.1002/pro.4516

Kynast, Josef ; Höcker, Birte:
Atligator Web: A Graphical User Interface for Analysis and Design of Protein–Peptide Interactions.
In: BioDesign Research. Bd. 5 (2023) . - 0011.
DOI: https://doi.org/10.34133/bdr.0011

Höcker, Birte ; Lu, Peilong ; Glasgow, Anum ; Marks, Debora S. ; Chatterjee, Pranam ; Slusky, Joanna S. G. ; Schueler-Furman, Ora ; Huang, Possu:
How can the protein design community best support biologists who want to harness AI tools for protein structure prediction and design?
In: Cell Systems. Bd. 14 (2023) Heft 8 . - S. 629-632.
DOI: https://doi.org/10.1016/j.cels.2023.07.005

Kordes, Sina ; Beck, Julian ; Shanmugaratnam, Sooruban ; Flecks, Merle ; Höcker, Birte:
Physics-based approach to extend a de novo TIM barrel with rationally designed helix-loop-helix motifs.
In: Protein Engineering, Design & Selection. Bd. 36 (2023) . - gzad012.
DOI: https://doi.org/10.1093/protein/gzad012

Michel, Florian ; Romero-Romero, Sergio ; Höcker, Birte:
Retracing the evolution of a modern periplasmic binding protein.
In: Protein Science. Bd. 32 (2023) Heft 11 . - e4793.
DOI: https://doi.org/10.1002/pro.4793

Michel, Florian ; Shanmugaratnam, Sooruban ; Romero-Romero, Sergio ; Höcker, Birte:
Structures of permuted halves of a modern ribose-binding protein.
In: Acta Crystallographica Section D Structural Biology. Bd. 79 (2023) . - S. 40-49.
DOI: https://doi.org/10.1107/S205979832201186X

Kynast, Josef ; Schwägerl, Felix ; Höcker, Birte:
ATLIGATOR : editing protein interactions with an atlas-based approach.
In: Bioinformatics. Bd. 38 (2022) Heft 23 . - S. 5199-5205.
DOI: https://doi.org/10.1093/bioinformatics/btac685

Rhys, Guto G. ; Cross, Jessica A. ; Dawson, William M. ; Thompson, Harry F. ; Shanmugaratnam, Sooruban ; Savery, Nigel J. ; Dodding, Mark P. ; Höcker, Birte ; Woolfson, Derek N.:
De novo designed peptides for cellular delivery and subcellular localisation.
In: Nature Chemical Biology. Bd. 18 (2022) Heft 9 . - S. 999-1004.
DOI: https://doi.org/10.1038/s41589-022-01076-6

Ferruz, Noelia ; Höcker, Birte:
Dreaming ideal protein structures.
In: Nature Biotechnology. Bd. 40 (2022) Heft 2 . - S. 171-172.
DOI: https://doi.org/10.1038/s41587-021-01196-9

Weigert, Sebastian ; Perez‐Garcia, Pablo ; Gisdon, Florian J. ; Gagsteiger, Andreas ; Schweinshaut, Kristine ; Ullmann, G. Matthias ; Chow, Jennifer ; Streit, Wolfgang R. ; Höcker, Birte:
Investigation of the halophilic PET hydrolase PET6 from Vibrio gazogenes.
In: Protein Science. Bd. 31 (2022) Heft 12 . - e4500.
DOI: https://doi.org/10.1002/pro.4500

Gisdon, Florian J. ; Kynast, Josef ; Ayyildiz, Merve ; Hine, Anna V. ; Plückthun, Andreas ; Höcker, Birte:
Modular peptide binders : development of a predictive technology as alternative for reagent antibodies.
In: Biological Chemistry. Bd. 403 (2022) Heft 5-6 . - S. 535-543.
DOI: https://doi.org/10.1515/hsz-2021-0384

Kordes, Sina ; Romero-Romero, Sergio ; Lutz, Leonie ; Höcker, Birte:
A newly introduced salt bridge cluster improves structural and biophysical properties of de novo TIM barrels.
In: Protein Science. Bd. 31 (2022) Heft 2 . - S. 513-527.
DOI: https://doi.org/10.1002/pro.4249

Höcker, Birte ; Zielonka, Stefan:
Protein engineering & design : hitting new heights.
In: Biological Chemistry. Bd. 403 (2022) Heft 5-6 . - S. 453.
DOI: https://doi.org/10.1515/hsz-2022-0139

Ferruz, Noelia ; Schmidt, Steffen ; Höcker, Birte:
ProtGPT2 is a deep unsupervised language model for protein design.
In: Nature Communications. Bd. 13 (2022) . - 4348.
DOI: https://doi.org/10.1038/s41467-022-32007-7

Ferruz, Noelia ; Höcker, Birte:
Controllable protein design with language models.
In: Nature Machine Intelligence. Bd. 4 (2022) . - S. 521-532.
DOI: https://doi.org/10.1038/s42256-022-00499-z

Lechner, Horst ; Emann, Vincent R. ; Breuning, Matthias ; Höcker, Birte:
An Artificial Cofactor Catalyzing the Baylis-Hillman Reaction with Designed Streptavidin as Protein Host.
In: ChemBioChem. Bd. 22 (2021) Heft 9 . - S. 1573-1577.
DOI: https://doi.org/10.1002/cbic.202000880

Zhang, Hongli ; Perez-Garcia, Pablo ; Dierkes, Robert F. ; Applegate, Violetta ; Schumacher, Julia ; Chibani, Cynthia Maria ; Sternagel, Stefanie ; Preuss, Lena ; Weigert, Sebastian ; Schmeisser, Christel ; Danso, Dominik ; Pleiss, Juergen ; Almeida, Alexandre ; Höcker, Birte ; Hallam, Steven J. ; Schmitz, Ruth A. ; Smits, Sander H. J. ; Chow, Jennifer ; Streit, Wolfgang R.:
The Bacteroidetes Aequorivita sp. and Kaistella jeonii Produce Promiscuous Esterases With PET-Hydrolyzing Activity.
In: Frontiers in Microbiology. Bd. 12 (2021) . - 803896.
DOI: https://doi.org/10.3389/fmicb.2021.803896

Herud-Sikimić, Ole ; Stiel, André C. ; Kolb, Martina ; Shanmugaratnam, Sooruban ; Berendzen, Kenneth W. ; Feldhaus, Christian ; Höcker, Birte ; Jürgens, Gerd:
A biosensor for the direct visualization of auxin.
In: Nature. Bd. 592 (2021) Heft 7856 . - S. 768-772.
DOI: https://doi.org/10.1038/s41586-021-03425-2

Romero-Romero, Sergio ; Kordes, Sina ; Michel, Florian ; Höcker, Birte:
Evolution, folding, and design of TIM barrels and related proteins.
In: Current Opinion in Structural Biology. Bd. 68 (2021) . - S. 94-104.
DOI: https://doi.org/10.1016/j.sbi.2020.12.007

Wiese, Jonas Gregor ; Shanmugaratnam, Sooruban ; Höcker, Birte:
Extension of a de novo TIM barrel with a rationally designed secondary structure element.
In: Protein Science. Bd. 30 (2021) Heft 5 . - S. 982-989.
DOI: https://doi.org/10.1002/pro.4064

Kröger, Pascal ; Shanmugaratnam, Sooruban ; Scheib, Ulrike ; Höcker, Birte:
Fine-tuning spermidine binding modes in the putrescine binding protein PotF.
In: The Journal of Biological Chemistry. Bd. 297 (2021) Heft 6 . - 101419.
DOI: https://doi.org/10.1016/j.jbc.2021.101419

Ferruz, Noelia ; Michel, Florian ; Lobos, Francisco ; Schmidt, Steffen ; Höcker, Birte:
Fuzzle 2.0 : Ligand Binding in Natural Protein Building Blocks.
In: Frontiers in Molecular Biosciences. Bd. 8 (2021) . - 715972.
DOI: https://doi.org/10.3389/fmolb.2021.715972

Menzel, Teresa ; Weigert, Sebastian ; Gagsteiger, Andreas ; Eich, Yannik ; Sittl, Sebastian ; Papastavrou, Georg ; Ruckdäschel, Holger ; Altstädt, Volker ; Höcker, Birte:
Impact of Enzymatic Degradation on the Material Properties of Poly(Ethylene Terephthalate).
In: Polymers. Bd. 13 (2021) Heft 22 . - 3885.
DOI: https://doi.org/10.3390/polym13223885

Ferruz, Noelia ; Schmidt, Steffen ; Höcker, Birte:
ProteinTools : a toolkit to analyze protein structures.
In: Nucleic Acids Research. Bd. 49 (2021) Heft W1 . - W559-W566.
DOI: https://doi.org/10.1093/nar/gkab375

Weigert, Sebastian ; Gagsteiger, Andreas ; Menzel, Teresa ; Höcker, Birte:
A versatile assay platform for enzymatic poly(ethylene-terephthalate) degradation.
In: Protein Engineering, Design & Selection. Bd. 34 (2021) . - S. 1-9.
DOI: https://doi.org/10.1093/protein/gzab022

Romero-Romero, Sergio ; Costas, Miguel ; Silva Manzano, Daniel-Adriano ; Kordes, Sina ; Rojas-Ortega, Erendira ; Tapia, Cinthya ; Guerra, Yasel ; Shanmugaratnam, Sooruban ; Rodríguez-Romero, Adela ; Baker, David ; Höcker, Birte ; Fernández-Velasco, D. Alejandro:
The Stability Landscape of de novo TIM Barrels Explored by a Modular Design Approach.
In: Journal of Molecular Biology. Bd. 433 (2021) Heft 18 . - 167153.
DOI: https://doi.org/10.1016/j.jmb.2021.167153

Ferruz, Noelia ; Lobos, Francisco ; Lemm, Dominik ; Toledo-Patiño, Saacnicteh ; Farías-Rico, José Arcadio ; Schmidt, Steffen ; Höcker, Birte:
Identification and Analysis of Natural Building Blocks for Evolution-Guided Fragment-Based Protein Design.
In: Journal of Molecular Biology. Bd. 432 (2020) Heft 13 . - S. 3898-3914.
DOI: https://doi.org/10.1016/j.jmb.2020.04.013

Linke, Heiner ; Höcker, Birte ; Furuta, Ken'ya ; Forde, Nancy R. ; Curmi, Paul M. G.:
Synthetic biology approaches to dissecting linear motor protein function : towards the design and synthesis of artificial autonomous protein walkers.
In: Biophysical Reviews. Bd. 12 (2020) Heft 4 . - S. 1041-1054.
DOI: https://doi.org/10.1007/s12551-020-00717-1

Toledo-Patiño, Saacnicteh ; Chaubey, Manish ; Coles, Murray ; Höcker, Birte:
Reconstructing the Remote Origins of a Fold Singleton from a Flavodoxin-Like Ancestor.
In: Biochemistry. Bd. 58 (2019) Heft 48 . - S. 4790-4793.
DOI: https://doi.org/10.1021/acs.biochem.9b00900

Höcker, Birte ; Winther, Jakob R.:
Editorial overview : A perspective on protein evolution.
In: Current Opinion in Structural Biology. Bd. 48 (2018) . - S. viii-ix.
DOI: https://doi.org/10.1016/j.sbi.2018.01.013

Lichtenstein, Bruce R. ; Höcker, Birte:
Engineering an AB₅ Protein Carrier.
In: Scientific Reports. Bd. 8 (2018) . - 12643.
DOI: https://doi.org/10.1038/s41598-018-30910-y

Banda-Vázquez, Jesús ; Shanmugaratnam, Sooruban ; Rodríguez-Sotres, Rogelio ; Torres-Larios, Alfredo ; Höcker, Birte ; Sosa-Peinado, Alejandro:
Redesign of LAOBP to bind novel l-amino acid ligands.
In: Protein Science. Bd. 27 (2018) Heft 5 . - S. 957-968.
DOI: https://doi.org/10.1002/pro.3403

Lechner, Horst ; Ferruz, Noelia ; Höcker, Birte:
Strategies for designing non-natural enzymes and binders.
In: Current Opinion in Chemical Biology. Bd. 47 (2018) . - S. 67-76.
DOI: https://doi.org/10.1016/j.cbpa.2018.07.022

Toledo-Patiño, Saacnicteh ; Lobos, Francisco ; Höcker, Birte:
Baukasten der Natur : Neue Proteine aus konservierten Fragmenten.
In: BIOspektrum. Bd. 23 (2017) Heft 6 . - S. 630-633.
DOI: https://doi.org/10.1007/s12268-017-0847-8

Sterner, Reinhard ; Höcker, Birte ; Kolmar, Harald:
Highlight issue: protein design.
In: Biological Chemistry. Bd. 398 (2017) Heft 1 . - S. 1-2.
DOI: https://doi.org/10.1515/hsz-2016-0322

Huang, Po-Ssu ; Feldmeier, Kaspar ; Parmeggiani, Fabio ; Velasco, D Alejandro Fernandez ; Höcker, Birte ; Baker, David:
De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy.
In: Nature Chemical Biology. Bd. 12 (2016) Heft 1 . - S. 29-34.
DOI: https://doi.org/10.1038/nchembio.1966

Scheib, Ulrike ; Shanmugaratnam, Sooruban ; Farías-Rico, José Arcadio ; Höcker, Birte:
Change in protein-ligand specificity through binding pocket grafting.
In: Journal of Structural Biology. Bd. 185 (2014) Heft 2 . - S. 186-192.
DOI: https://doi.org/10.1016/j.jsb.2013.06.002

Höcker, Birte:
Design of proteins from smaller fragments : learning from evolution.
In: Current Opinion in Structural Biology. Bd. 27 (2014) . - S. 56-62.
DOI: https://doi.org/10.1016/j.sbi.2014.04.007

Höcker, Birte ; Midelfort, Katarina:
Designing protein function : macromolecular design.
In: Journal of Structural Biology. Bd. 185 (2014) Heft 2 . - S. 135.
DOI: https://doi.org/10.1016/j.jsb.2014.01.011

Farías-Rico, José Arcadio ; Schmidt, Steffen ; Höcker, Birte:
Evolutionary relationship of two ancient protein superfolds.
In: Nature Chemical Biology. Bd. 10 (2014) Heft 9 . - S. 710-715.
DOI: https://doi.org/10.1038/nchembio.1579

Feldmeier, Kaspar ; Höcker, Birte:
Computational protein design of ligand binding and catalysis.
In: Current Opinion in Chemical Biology. Bd. 17 (2013) Heft 6 . - S. 929-933.
DOI: https://doi.org/10.1016/j.cbpa.2013.10.002

Höcker, Birte:
Engineering chimaeric proteins from fold fragments : "hopeful monsters" in protein design.
In: Biochemical Society Transactions. Bd. 41 (2013) Heft 5 . - S. 1137-1140.
DOI: https://doi.org/10.1042/BST20130099

Meier, Monika M. ; Rajendran, Chitra ; Malisi, Christoph ; Fox, Nicholas G. ; Xu, Chengfu ; Schlee, Sandra ; Barondeau, David P. ; Höcker, Birte ; Sterner, Reinhard ; Raushel, Frank M.:
Molecular engineering of organophosphate hydrolysis activity from a weak promiscuous lactonase template.
In: Journal of the American Chemical Society. Bd. 135 (2013) Heft 31 . - S. 11670-11677.
DOI: https://doi.org/10.1021/ja405911h

Malisi, Christoph ; Schumann, Marcel ; Toussaint, Nora C ; Kageyama, Jorge ; Kohlbacher, Oliver ; Höcker, Birte:
Binding pocket optimization by computational protein design.
In: PLoS One. Bd. 7 (2012) Heft 12 . - e52505.
DOI: https://doi.org/10.1371/journal.pone.0052505

Shanmugaratnam, Sooruban ; Eisenbeis, Simone ; Höcker, Birte:
A highly stable protein chimera built from fragments of different folds.
In: Protein Engineering, Design & Selection. Bd. 25 (2012) Heft 11 . - S. 699-703.
DOI: https://doi.org/10.1093/protein/gzs074

Eisenbeis, Simone ; Proffitt, William ; Coles, Murray ; Truffault, Vincent ; Shanmugaratnam, Sooruban ; Meiler, Jens ; Höcker, Birte:
Potential of fragment recombination for rational design of proteins.
In: Journal of the American Chemical Society. Bd. 134 (2012) Heft 9 . - S. 4019-4022.
DOI: https://doi.org/10.1021/ja211657k

Höcker, Birte:
Protein design : A metalloenzyme reloaded.
In: Nature Chemical Biology. Bd. 8 (2012) Heft 3 . - S. 224-225.
DOI: https://doi.org/10.1038/nchembio.800

Höcker, Birte:
Structural biology : A toolbox for protein design.
In: Nature. Bd. 491 (2012) Heft 7423 . - S. 204-205.
DOI: https://doi.org/10.1038/491204a

Malisi, Christoph ; Stiel, André C. ; Höcker, Birte:
Enzyme am Reißbrett.
In: BIOspektrum. Bd. 17 (2011) Heft 7 . - S. 736-738.
DOI: https://doi.org/10.1007/s12268-011-0117-0

Schreier, Bettina ; Höcker, Birte:
Engineering the enolase magnesium II binding site: implications for its evolution.
In: Biochemistry. Bd. 49 (2010) Heft 35 . - S. 7582-7589.
DOI: https://doi.org/10.1021/bi100954f

Eisenbeis, Simone ; Höcker, Birte:
Evolutionary mechanism as a template for protein engineering.
In: Journal of Peptide Science. Bd. 16 (2010) Heft 10 . - S. 538-544.
DOI: https://doi.org/10.1002/psc.1233

Höcker, Birte:
Metals make proteins stick.
In: Chemistry & Biology. Bd. 17 (2010) Heft 2 . - S. 103-104.
DOI: https://doi.org/10.1016/j.chembiol.2010.02.002

Malisi, Christoph ; Kohlbacher, Oliver ; Höcker, Birte:
Automated scaffold selection for enzyme design.
In: Proteins: Structure, Function, and Bioinformatics. Bd. 77 (2009) Heft 1 . - S. 74-83.
DOI: https://doi.org/10.1002/prot.22418

Schreier, Bettina ; Stumpp, Christian ; Wiesner, Silke ; Höcker, Birte:
Computational design of ligand binding is not a solved problem.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 106 (2009) Heft 44 . - S. 18491-18496.
DOI: https://doi.org/10.1073/pnas.0907950106

Claren, Jörg ; Malisi, Christoph ; Höcker, Birte ; Sterner, Reinhard:
Establishing wild-type levels of catalytic activity on natural and artificial (βα)8-barrel protein scaffolds.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 106 (2009) Heft 10 . - S. 3704-3709.
DOI: https://doi.org/10.1073/pnas.0810342106

Höcker, Birte ; Lochner, Adriane ; Seitz, Tobias ; Claren, Jörg ; Sterner, Reinhard:
High-resolution crystal structure of an artificial (βα)₈-barrel protein designed from identical half-barrels.
In: Biochemistry. Bd. 48 (2009) Heft 6 . - S. 1145-1147.
DOI: https://doi.org/10.1021/bi802125b

Bharat, Tanmay A. M. ; Eisenbeis, Simone ; Zeth, Kornelius ; Höcker, Birte:
A βα-barrel built by the combination of fragments from different folds.
In: Proceedings of the National Academy of Sciences of the United States of America. Bd. 105 (2008) Heft 29 . - S. 9942-9947.
DOI: https://doi.org/10.1073/pnas.0802202105

Reetz, Manfred T. ; Rentzsch, Martin ; Pletsch, Andreas ; Taglieber, Andreas ; Hollmann, Frank ; Mondière, Régis J. G. ; Dickmann, Norbert ; Höcker, Birte ; Cerrone, Simona ; Haeger, Michaela C. ; Sterner, Reinhard:
A robust protein host for anchoring chelating ligands and organocatalysts.
In: ChemBioChem. Bd. 9 (2008) Heft 4 . - S. 552-564.
DOI: https://doi.org/10.1002/cbic.200700413

Sterner, Reinhard ; Höcker, Birte:
Catalytic versatility, stability, and evolution of the (betaalpha)8-barrel enzyme fold.
In: Chemical Reviews. Bd. 105 (2005) Heft 11 . - S. 4038-4055.
DOI: https://doi.org/10.1021/cr030191z

Höcker, Birte:
Directed evolution of (βα)₈-barrel enzymes.
In: Biomolecular Engineering. Bd. 22 (2005) Heft 1-3 . - S. 31-38.
DOI: https://doi.org/10.1016/j.bioeng.2004.09.005

Höcker, Birte ; Schmidt, Steffen ; Sterner, Reinhard:
A common evolutionary origin of two elementary enzyme folds.
In: FEBS Letters. Bd. 510 (2002) Heft 3 . - S. 133-135.
DOI: https://doi.org/10.1016/S0014-5793(01)03232-X

Raasch, Carsten ; Armbrecht, Martin ; Streit, Wolfgang R. ; Höcker, Birte ; Sträter, Norbert ; Liebl, Wolfgang:
Identification of residues important for NAD+ binding by the Thermotoga maritima alpha-glucosidase AglA, a member of glycoside hydrolase family 4.
In: FEBS Letters. Bd. 517 (2002) Heft 1-3 . - S. 267-271.
DOI: https://doi.org/10.1016/S0014-5793(02)02641-8

Höcker, Birte ; Beismann-Driemeyer, Silke ; Hettwer, Stefan ; Lustig, Ariel ; Sterner, Reinhard:
Dissection of a (betaalpha)8-barrel enzyme into two folded halves.
In: Nature Structural Biology. Bd. 8 (2001) Heft 1 . - S. 32-36.
DOI: https://doi.org/10.1038/83021

Henn-Sax, Martina ; Höcker, Birte ; Wilmanns, Matthias ; Sterner, Reinhard:
Divergent evolution of (β⍺)₈-barrel enzymes.
In: Biological Chemistry. Bd. 382 (2001) Heft 9 . - S. 1315-1320.
DOI: https://doi.org/10.1515/BC.2001.163

Höcker, Birte ; Jürgens, Catharina ; Wilmanns, Matthias ; Sterner, Reinhard:
Stability, catalytic versatility and evolution of the (betaalpha)(8)-barrel fold.
In: Current Opinion in Biotechnology. Bd. 12 (2001) Heft 4 . - S. 376-381.
DOI: https://doi.org/10.1016/S0958-1669(00)00230-5

Aufsatz in einem Buch

Stiel, André C. ; Nellen, Mehdi ; Höcker, Birte:
PocketOptimizer and the Design of Ligand Binding Sites.
In: Stoddard, Barry L. (Hrsg.): Computational Design of Ligand Binding Proteins. - New York : Humana Press, 2016 . - S. 63-75 . - (Methods in Molecular Biology ; 1414 )
DOI: https://doi.org/10.1007/978-1-4939-3569-7_5

Stiel, André C. ; Feldmeier, Kaspar ; Höcker, Birte:
Identification of protein scaffolds for enzyme design using scaffold selection.
In: Köhler, Valentin (Hrsg.): Protein design : methods and applications. 2nd Edition. - New York, NY : Humana Press, 2014 . - S. 183-196 . - (Methods in Molecular Biology ; 1216 )
DOI: https://doi.org/10.1007/978-1-4939-1486-9_9

Farías-Rico, José Arcadio ; Höcker, Birte:
Design of chimeric proteins by combination of subdomain-sized fragments.
In: Keating, Amy E. (Hrsg.): Methods in protein design. - Amsterdam : Academic Press, 2013 . - S. 389-405 . - (Methods in Enzymology ; 523 )
DOI: https://doi.org/10.1016/B978-0-12-394292-0.00018-7

Preprint, Postprint

Nilsson, Patrik Felix ; Zink, Anna ; Laprévote, Olivier ; Korosec, Chapin S. ; Gustafsson, Nils ; Robertson, Neil O. ; Forde, Nancy ; Eichhorn, Ralf ; Höcker, Birte ; Curmi, Paul ; Linke, Heiner:
Walking by design: how to build artificial molecular motors made of proteins.
Bayreuth , 2024
DOI: https://doi.org/10.1088/2399-1984/ad7d7e

Kröger, Pascal ; Stiel, Andre C. ; Stüven, Birthe ; Shanmugaratnam, Sooruban ; Schoch, Susanne ; Wachten, Dagmar ; Höcker, Birte:
A fluorescent biosensor for the visualization of agmatine.
Bayreuth , 2024
DOI: https://doi.org/10.1101/2024.07.27.605435

Dissertation

Beck, Julian:
Functionalization of de novo TIM barrels.
Bayreuth , 2026 . - VII,110 S.
( Dissertation, 2026 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00009131

Kröger, Pascal:
Characterization and engineering of ligand binding in the periplasmic binding protein PotF.
Bayreuth , 2025 . - IX, 115 S.
( Dissertation, 2023 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00006866

Ayyildiz, Merve:
Computational Design & Analysis of Specific Binding Pockets for Natural and Modified Amino Acids.
Bayreuth , 2025 . - VI, 137 S.
( Dissertation, 2025 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00008572

Michel, Florian:
Investigations into the evolution of a periplasmic binding protein and its implications in the origins of modern protein folds.
Bayreuth , 2025 . - 137 S.
( Dissertation, 2024 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00008207

Kempf, Oxana:
Synthesis of glutathione analogues to investigate the enzymatic mechanism of phytochelatin synthase by fluorescence spectroscopy.
Bayreuth , 2025 . - 69 S.
( Dissertation, 2022 , Universität Bayreuth, Bayreuther Graduiertenschule für Mathematik und Naturwissenschaften - BayNAT)
DOI: https://doi.org/10.15495/EPub_UBT_00006819

Kynast, Josef:
Towards Modular Protein Detection : Computational Methods to Support the Design of Peptide-Binding Pockets.
Bayreuth , 2024 . - X, 83 S.
( Dissertation, 2024 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00007497

Kordes, Sina:
TIM Barrels 2.0 – Stabilizing and Diversifying a De Novo Designed Protein.
Bayreuth , 2023 . - ii, 190 S.
( Dissertation, 2022 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00006859

Weigert, Sebastian:
Investigation of PET-degrading enzymes and their implications on microplastics.
Bayreuth , 2022 . - IV, 112 S.
( Dissertation, 2022 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00006729

You, Weijie:
Activation and inhibition of Sirt6 by small molecules.
Bayreuth , 2019 . - 120 S.
( Dissertation, 2019 , Universität Bayreuth, Fakultät für Biologie, Chemie und Geowissenschaften)
DOI: https://doi.org/10.15495/EPub_UBT_00004450

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